Version history

{
  "scope": "mouse (adult genetic ablation)",
  "claim_text": "Diphtheria-toxin ablation of NPY/AgRP neurons in adult mice produces severe hypophagia and loss of body weight, demonstrating that AGRP neurons are necessary for normal feeding in the adult animal — directly conflicting with the developmental compensation seen when these neurons are removed neonatally.",
  "raw_fields": {
    "n": null,
    "doi": "10.1126/science.1115524",
    "claim": "Diphtheria-toxin ablation of NPY/AgRP neurons in adult mice produces severe hypophagia and loss of body weight, demonstrating that AGRP neurons are necessary for normal feeding in the adult animal — directly conflicting with the developmental compensation seen when these neurons are removed neonatally.",
    "cite_key": "Luquet2005",
    "evidence": "abstract_only",
    "effect_size": null,
    "text_access": "abstract",
    "study_system": "mouse (adult genetic ablation)",
    "source_cluster_id": "cluster_08",
    "replication_status": "unreplicated",
    "claim_source_sentence": "To determine whether NPY/AgRP neurons are essential in mice, we targeted the human diphtheria toxin receptor to the Agrp locus, which allows temporally controlled ablation of NPY/AgRP neurons to occur after an injection of diphtheria toxin.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_09_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-09",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-1fb7df45b557"
  ],
  "source_span": "To determine whether NPY/AgRP neurons are essential in mice, we targeted the human diphtheria toxin receptor to the Agrp locus, which allows temporally controlled ablation of NPY/AgRP neurons to occur after an injection of diphtheria toxin.",
  "study_system": "mouse (adult genetic ablation)",
  "evidence_refs": [
    {
      "ref": "paper:paper-1fb7df45b557"
    }
  ],
  "section_title": "The Hypothalamic Extension: Loops for Motivated Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "abstract_only",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "unreplicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-09",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_09_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}