Version history

{
  "scope": "mouse MGE in vitro and TrkB knockout in vivo",
  "claim_text": "Tangential migration of MGE-derived cortical interneurons is stimulated by BDNF/NT4 acting via TrkB and PI3-kinase; TrkB-null mice show fewer calbindin+ neurons migrating in embryonic cortex.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1242/dev.129.13.3147",
    "claim": "Tangential migration of MGE-derived cortical interneurons is stimulated by BDNF/NT4 acting via TrkB and PI3-kinase; TrkB-null mice show fewer calbindin+ neurons migrating in embryonic cortex.",
    "title": null,
    "cite_key": "Polleux2002",
    "evidence": "In vitro migration assay with time-lapse imaging, pharmacological inhibitors, and TrkB-null mouse genetics.",
    "effect_size": "qualitative significant decrease in TrkB-null",
    "text_access": "abstract_only",
    "study_system": "mouse MGE in vitro and TrkB knockout in vivo",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 44,
    "claim_source_sentence": "Tangential migration is strongly stimulated by BDNF and NT4 and attenuated by the Trk-family inhibitor, K252a, suggesting that migration is regulated by TrkB signaling.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "TrkB-null mice show a significant decrease in the number of calbindin-positive neurons migrating tangentially in the embryonic cortex."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "qualitative significant decrease in TrkB-null",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-6558a3313af4"
  ],
  "source_span": "Tangential migration is strongly stimulated by BDNF and NT4 and attenuated by the Trk-family inhibitor, K252a, suggesting that migration is regulated by TrkB signaling.",
  "study_system": "mouse MGE in vitro and TrkB knockout in vivo",
  "evidence_refs": [
    {
      "ref": "paper:paper-6558a3313af4"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "In vitro migration assay with time-lapse imaging, pharmacological inhibitors, and TrkB-null mouse genetics.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}