Tangential migration of MGE-derived cortical interneurons is stimulated by BDNF…

{
  "n": 0,
  "doi": "10.1242/dev.129.13.3147",
  "claim": "Tangential migration of MGE-derived cortical interneurons is stimulated by BDNF/NT4 acting via TrkB and PI3-kinase; TrkB-null mice show fewer calbindin+ neurons migrating in embryonic cortex.",
  "title": null,
  "cite_key": "Polleux2002",
  "evidence": "In vitro migration assay with time-lapse imaging, pharmacological inhibitors, and TrkB-null mouse genetics.",
  "effect_size": "qualitative significant decrease in TrkB-null",
  "text_access": "abstract_only",
  "study_system": "mouse MGE in vitro and TrkB knockout in vivo",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 44,
  "claim_source_sentence": "Tangential migration is strongly stimulated by BDNF and NT4 and attenuated by the Trk-family inhibitor, K252a, suggesting that migration is regulated by TrkB signaling.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "TrkB-null mice show a significant decrease in the number of calbindin-positive neurons migrating tangentially in the embryonic cortex."
}

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