Synthesis: in mouse cortex, laminar architecture systematically constrains long…

Synthesis: in mouse cortex, laminar architecture systematically constrains long-range interareal communication, with cortico-cortical pathways differing by source and target lamina and by selective targeting of excitatory vs. inhibitory populations, producing layer-specific computations.

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  "doi": "10.3389/fnana.2017.00071",
  "claim": "Synthesis: in mouse cortex, laminar architecture systematically constrains long-range interareal communication, with cortico-cortical pathways differing by source and target lamina and by selective targeting of excitatory vs. inhibitory populations, producing layer-specific computations.",
  "cite_key": "DSouza2017",
  "evidence": "Synthetic review of mouse visual cortical network, integrating laminar termination patterns, cell-type targeting and L1 architecture across multiple primary studies.",
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By originating and terminating in different laminae, and by selectively targeting specific populations of excitatory and inhibitory neurons, these "interareal" pathways can differentially control the timing and strength of synaptic inputs onto individual neurons, resulting in layer-specific computations.

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