Version history

{
  "scope": "mouse V1; in vivo 2P imaging",
  "claim_text": "Disinhibitory VIP→SST motif in V1 is context-dependent: in darkness locomotion activates VIP and inhibits SST (canonical disinhibition), but in the presence of visual stimuli locomotion increases SST responses to large stimuli AND VIP responses to small stimuli — requiring an extension beyond the classical disinhibition model.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2018.03.037",
    "claim": "Disinhibitory VIP→SST motif in V1 is context-dependent: in darkness locomotion activates VIP and inhibits SST (canonical disinhibition), but in the presence of visual stimuli locomotion increases SST responses to large stimuli AND VIP responses to small stimuli — requiring an extension beyond the classical disinhibition model.",
    "title": null,
    "cite_key": "Dipoppa2018",
    "evidence": "In vivo two-photon Ca2+ imaging of all four cell types (Pyr/SST/VIP/PV) in mouse V1 with locomotion + visual stimuli; recurrent network model.",
    "effect_size": "Visual stimulus reverses canonical VIP-SST anti-correlation; recurrent network model required.",
    "text_access": "fulltext",
    "study_system": "mouse V1; in vivo 2P imaging",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "replicates",
    "_source_cluster_index": 32,
    "claim_source_sentence": "Our recordings in darkness were consistent with a \"disinhibitory\" model in which locomotion activates Vip cells, thus inhibiting Sst cells and disinhibiting Pyr cells. However, the disinhibitory model failed when visual stimuli were present: locomotion increased Sst cell responses to large stimuli and Vip cell responses to small stimuli.",
    "replication_evidence_dois": [
      "10.7554/elife.14985",
      "10.1016/j.cell.2014.01.050"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "Visual stimulus reverses canonical VIP-SST anti-correlation; recurrent network model required.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-f457e091013f"
  ],
  "source_span": "Our recordings in darkness were consistent with a \"disinhibitory\" model in which locomotion activates Vip cells, thus inhibiting Sst cells and disinhibiting Pyr cells. However, the disinhibitory model failed when visual stimuli were present: locomotion increased Sst cell responses to large stimuli and Vip cell responses to small stimuli.",
  "study_system": "mouse V1; in vivo 2P imaging",
  "evidence_refs": [
    {
      "ref": "paper:paper-f457e091013f"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "In vivo two-photon Ca2+ imaging of all four cell types (Pyr/SST/VIP/PV) in mouse V1 with locomotion + visual stimuli; recurrent network model.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicates",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}