- claim_text
Disinhibitory VIP→SST motif in V1 is context-dependent: in darkness locomotion activates VIP and inhibits SST (canonical disinhibition), but in the presence of visual stimuli locomotion increases SST responses to large stimuli AND VIP responses to small stimuli — requiring an extension beyond the classical disinhibition model.
- raw_fields
{
"n": null,
"doi": "10.1016/j.neuron.2018.03.037",
"claim": "Disinhibitory VIP→SST motif in V1 is context-dependent: in darkness locomotion activates VIP and inhibits SST (canonical disinhibition), but in the presence of visual stimuli locomotion increases SST responses to large stimuli AND VIP responses to small stimuli — requiring an extension beyond the classical disinhibition model.",
"title": null,
"cite_key": "Dipoppa2018",
"evidence": "In vivo two-photon Ca2+ imaging of all four cell types (Pyr/SST/VIP/PV) in mouse V1 with locomotion + visual stimuli; recurrent network model.",
"effect_size": "Visual stimulus reverses canonical VIP-SST anti-correlation; recurrent network model required.",
"text_access": "fulltext",
"study_system": "mouse V1; in vivo 2P imaging",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "replicates",
"_source_cluster_index": 32,
"claim_source_sentence": "Our recordings in darkness were consistent with a \"disinhibitory\" model in which locomotion activates Vip cells, thus inhibiting Sst cells and disinhibiting Pyr cells. However, the disinhibitory model failed when visual stimuli were present: locomotion increased Sst cell responses to large stimuli and Vip cell responses to small stimuli.",
"replication_evidence_dois": [
"10.7554/elife.14985",
"10.1016/j.cell.2014.01.050"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-f457e091013f"
]
- source_span
Our recordings in darkness were consistent with a "disinhibitory" model in which locomotion activates Vip cells, thus inhibiting Sst cells and disinhibiting Pyr cells. However, the disinhibitory model failed when visual stimuli were present: locomotion increased Sst cell responses to large stimuli and Vip cell responses to small stimuli.
- evidence_refs
[
{
"ref": "paper:paper-f457e091013f"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}