Version history

{
  "scope": "Mouse; cingulate→V1 cortico-cortical projection optogenetics + behavior.",
  "claim_text": "Optogenetic activation of mouse cingulate frontal cortex (Cg) long-range axons in V1 enhances V1 responses and improves visual discrimination, with Cg→V1 modulation engaging local SST and PV GABAergic interneurons to produce center-surround sensory modulation.",
  "raw_fields": {
    "n": null,
    "doi": "10.1126/science.1254126",
    "claim": "Optogenetic activation of mouse cingulate frontal cortex (Cg) long-range axons in V1 enhances V1 responses and improves visual discrimination, with Cg→V1 modulation engaging local SST and PV GABAergic interneurons to produce center-surround sensory modulation.",
    "cite_key": "Zhang2014",
    "evidence": "Channelrhodopsin-based optogenetic activation of Cg neurons or Cg→V1 axons in mouse V1; behavioral visual-discrimination assays and cell-type-specific recordings.",
    "effect_size": "Cg activation enhances V1 responses and improves visual discrimination; focal Cg-axon activation produces center-surround modulation in V1.",
    "text_access": "abstract_only",
    "study_system": "Mouse; cingulate→V1 cortico-cortical projection optogenetics + behavior.",
    "argument_role": "supporting",
    "replication_status": "replicated",
    "claim_source_sentence": "We found that the cingulate (Cg) region of the mouse frontal cortex powerfully influences sensory processing in the primary visual cortex (V1) through long-range projections that activate local γ-aminobutyric acid-ergic (GABAergic) circuits.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2017.08.036"
    ],
    "effect_size_source_sentence": "Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "Cg activation enhances V1 responses and improves visual discrimination; focal Cg-axon activation produces center-surround modulation in V1.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-05bd6c97da43"
  ],
  "source_span": "We found that the cingulate (Cg) region of the mouse frontal cortex powerfully influences sensory processing in the primary visual cortex (V1) through long-range projections that activate local γ-aminobutyric acid-ergic (GABAergic) circuits.",
  "study_system": "Mouse; cingulate→V1 cortico-cortical projection optogenetics + behavior.",
  "evidence_refs": [
    {
      "ref": "paper:paper-05bd6c97da43"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Channelrhodopsin-based optogenetic activation of Cg neurons or Cg→V1 axons in mouse V1; behavioral visual-discrimination assays and cell-type-specific recordings.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}