- claim_text
Optogenetic activation of mouse cingulate frontal cortex (Cg) long-range axons in V1 enhances V1 responses and improves visual discrimination, with Cg→V1 modulation engaging local SST and PV GABAergic interneurons to produce center-surround sensory modulation.
- raw_fields
{
"n": null,
"doi": "10.1126/science.1254126",
"claim": "Optogenetic activation of mouse cingulate frontal cortex (Cg) long-range axons in V1 enhances V1 responses and improves visual discrimination, with Cg→V1 modulation engaging local SST and PV GABAergic interneurons to produce center-surround sensory modulation.",
"cite_key": "Zhang2014",
"evidence": "Channelrhodopsin-based optogenetic activation of Cg neurons or Cg→V1 axons in mouse V1; behavioral visual-discrimination assays and cell-type-specific recordings.",
"effect_size": "Cg activation enhances V1 responses and improves visual discrimination; focal Cg-axon activation produces center-surround modulation in V1.",
"text_access": "abstract_only",
"study_system": "Mouse; cingulate→V1 cortico-cortical projection optogenetics + behavior.",
"argument_role": "supporting",
"replication_status": "replicated",
"claim_source_sentence": "We found that the cingulate (Cg) region of the mouse frontal cortex powerfully influences sensory processing in the primary visual cortex (V1) through long-range projections that activate local γ-aminobutyric acid-ergic (GABAergic) circuits.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [
"10.1016/j.neuron.2017.08.036"
],
"effect_size_source_sentence": "Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination."
}- source_refs
[
"paper:paper-05bd6c97da43"
]
- source_span
We found that the cingulate (Cg) region of the mouse frontal cortex powerfully influences sensory processing in the primary visual cortex (V1) through long-range projections that activate local γ-aminobutyric acid-ergic (GABAergic) circuits.
- evidence_refs
[
{
"ref": "paper:paper-05bd6c97da43"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}