Spiking E/I network with VIP→SOM disinhibition shows that disrupting E/I ratio…

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  "doi": "10.1371/journal.pcbi.1013306",
  "pmid": "40768544",
  "year": "2025",
  "claim": "Spiking E/I network with VIP→SOM disinhibition shows that disrupting E/I ratio modulates synchrony and information flow directions, supporting top-down attentional modulation via the VIP-SOM gating mechanism.",
  "pmcid": "PMC12349708",
  "title": "Excitatory/inhibitory ratio disruption modulates neural synchrony and flow directions in a cortical microcircuit.",
  "authors": "Wagatsuma N, Nobukawa S, Kurikawa T.",
  "journal": "PLoS computational biology",
  "cite_key": "Wagatsuma2025a",
  "evidence": "Large-scale spiking simulation with parameterized E/I imbalance; transfer-entropy analyses confirm flow modulation.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "spiking E-I network + multiple interneurons",
  "_source_cluster": "cluster_11_computational_models",
  "replication_status": "replicated_independent",
  "_source_cluster_index": 84,
  "claim_source_sentence": "Recent computational studies suggest that local disinhibition by connections from VIP to SOM interneuron populations may be a plausible mechanism for the top-down attentional modulation of responses in the cortical microcircuit in layers 2/3 of the V1 [ 31 , 33 ].",
  "replication_evidence_dois": [
    "10.7554/elife.55130",
    "10.1523/jneurosci.1369-21.2021",
    "10.1038/s41598-017-01830-0",
    "10.1016/j.neuron.2021.11.016",
    "10.1073/pnas.2315160121"
  ],
  "effect_size_source_sentence": null
}

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]

Recent computational studies suggest that local disinhibition by connections from VIP to SOM interneuron populations may be a plausible mechanism for the top-down attentional modulation of responses in the cortical microcircuit in layers 2/3 of the V1 [ 31 , 33 ].

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