Version history

{
  "scope": "spiking E-I network + multiple interneurons",
  "claim_text": "Spiking E/I network with VIP→SOM disinhibition shows that disrupting E/I ratio modulates synchrony and information flow directions, supporting top-down attentional modulation via the VIP-SOM gating mechanism.",
  "raw_fields": {
    "n": null,
    "id": "cluster_11_finding_85",
    "doi": "10.1371/journal.pcbi.1013306",
    "pmid": "40768544",
    "year": "2025",
    "claim": "Spiking E/I network with VIP→SOM disinhibition shows that disrupting E/I ratio modulates synchrony and information flow directions, supporting top-down attentional modulation via the VIP-SOM gating mechanism.",
    "pmcid": "PMC12349708",
    "title": "Excitatory/inhibitory ratio disruption modulates neural synchrony and flow directions in a cortical microcircuit.",
    "authors": "Wagatsuma N, Nobukawa S, Kurikawa T.",
    "journal": "PLoS computational biology",
    "cite_key": "Wagatsuma2025a",
    "evidence": "Large-scale spiking simulation with parameterized E/I imbalance; transfer-entropy analyses confirm flow modulation.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "spiking E-I network + multiple interneurons",
    "_source_cluster": "cluster_11_computational_models",
    "replication_status": "replicated_independent",
    "_source_cluster_index": 84,
    "claim_source_sentence": "Recent computational studies suggest that local disinhibition by connections from VIP to SOM interneuron populations may be a plausible mechanism for the top-down attentional modulation of responses in the cortical microcircuit in layers 2/3 of the V1 [ 31 , 33 ].",
    "replication_evidence_dois": [
      "10.7554/elife.55130",
      "10.1523/jneurosci.1369-21.2021",
      "10.1038/s41598-017-01830-0",
      "10.1016/j.neuron.2021.11.016",
      "10.1073/pnas.2315160121"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_12",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-12-computational-models",
  "source_kind": "review_finding",
  "source_path": "evidence/section_12_evidence_package.json",
  "source_refs": [
    "paper:paper-088def893fc9"
  ],
  "source_span": "Recent computational studies suggest that local disinhibition by connections from VIP to SOM interneuron populations may be a plausible mechanism for the top-down attentional modulation of responses in the cortical microcircuit in layers 2/3 of the V1 [ 31 , 33 ].",
  "study_system": "spiking E-I network + multiple interneurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-088def893fc9"
    }
  ],
  "section_title": "Computational Models of VIP Circuit Function",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Large-scale spiking simulation with parameterized E/I imbalance; transfer-entropy analyses confirm flow modulation.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated_independent",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-12-computational-models",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}