Version history

{
  "scope": "mouse V1 in vivo 2-photon Ca2+ imaging + basal forebrain manipulation",
  "claim_text": "In vivo two-photon imaging in mouse V1 showed that basal forebrain cholinergic activation differentially modulates cortical interneuron classes — VIP and layer 1 interneurons are preferentially activated through nicotinic receptors during strong desynchronization, while excitatory and PV+ neurons engage muscarinic and nicotinic receptors with opposite signs at different arousal levels — substantiating cholinergic neuromodulation as a switch driving the canonical VIP disinhibitory motif.",
  "raw_fields": {
    "n": null,
    "doi": "10.3389/fnsys.2012.00079",
    "claim": "In vivo two-photon imaging in mouse V1 showed that basal forebrain cholinergic activation differentially modulates cortical interneuron classes — VIP and layer 1 interneurons are preferentially activated through nicotinic receptors during strong desynchronization, while excitatory and PV+ neurons engage muscarinic and nicotinic receptors with opposite signs at different arousal levels — substantiating cholinergic neuromodulation as a switch driving the canonical VIP disinhibitory motif.",
    "title": null,
    "cite_key": "Alitto2013",
    "evidence": "In vivo 2-photon Ca2+ imaging of L1/L2-3 mouse V1 + electrical/pharmacological basal-forebrain stimulation.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse V1 in vivo 2-photon Ca2+ imaging + basal forebrain manipulation",
    "target_section": "section_05",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "single_study",
    "_source_cluster_index": 85,
    "claim_source_sentence": "In contrast, vasoactive intestinal peptide-positive (VIP+) and layer 1 interneurons were preferentially activated through nAChRs during strong cortical desynchronization."
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-b336c49b4f54"
  ],
  "source_span": "In contrast, vasoactive intestinal peptide-positive (VIP+) and layer 1 interneurons were preferentially activated through nAChRs during strong cortical desynchronization.",
  "study_system": "mouse V1 in vivo 2-photon Ca2+ imaging + basal forebrain manipulation",
  "evidence_refs": [
    {
      "ref": "paper:paper-b336c49b4f54"
    }
  ],
  "section_title": "Species Differences, Human Relevance, and Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "In vivo 2-photon Ca2+ imaging of L1/L2-3 mouse V1 + electrical/pharmacological basal-forebrain stimulation.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}