In vivo two-photon imaging in mouse V1 showed that basal forebrain cholinergic…

In vivo two-photon imaging in mouse V1 showed that basal forebrain cholinergic activation differentially modulates cortical interneuron classes — VIP and layer 1 interneurons are preferentially activated through nicotinic receptors during strong desynchronization, while excitatory and PV+ neurons engage muscarinic and nicotinic receptors with opposite signs at different arousal levels — substantiating cholinergic neuromodulation as a switch driving the canonical VIP disinhibitory motif.

{
  "n": null,
  "doi": "10.3389/fnsys.2012.00079",
  "claim": "In vivo two-photon imaging in mouse V1 showed that basal forebrain cholinergic activation differentially modulates cortical interneuron classes — VIP and layer 1 interneurons are preferentially activated through nicotinic receptors during strong desynchronization, while excitatory and PV+ neurons engage muscarinic and nicotinic receptors with opposite signs at different arousal levels — substantiating cholinergic neuromodulation as a switch driving the canonical VIP disinhibitory motif.",
  "title": null,
  "cite_key": "Alitto2013",
  "evidence": "In vivo 2-photon Ca2+ imaging of L1/L2-3 mouse V1 + electrical/pharmacological basal-forebrain stimulation.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse V1 in vivo 2-photon Ca2+ imaging + basal forebrain manipulation",
  "target_section": "section_05",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "single_study",
  "_source_cluster_index": 85,
  "claim_source_sentence": "In contrast, vasoactive intestinal peptide-positive (VIP+) and layer 1 interneurons were preferentially activated through nAChRs during strong cortical desynchronization."
}

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