Version history

{
  "scope": "mouse, V1 and ALM cortex (adult)",
  "claim_text": "Six transcriptomic subclasses of GABAergic neurons (Sst, Pvalb, Vip, Lamp5, Sncg, Serpinf1) plus two distinct types (Sst-Chodl, Meis2-Adamts19) define mouse adult cortical interneuron taxonomy by single-cell RNA-seq, with the major division corresponding to MGE origin (Pvalb, Sst) versus CGE origin (Lamp5, Sncg, Serpinf1, Vip).",
  "raw_fields": {
    "n": 23822,
    "doi": "10.1038/s41586-018-0654-5",
    "claim": "Six transcriptomic subclasses of GABAergic neurons (Sst, Pvalb, Vip, Lamp5, Sncg, Serpinf1) plus two distinct types (Sst-Chodl, Meis2-Adamts19) define mouse adult cortical interneuron taxonomy by single-cell RNA-seq, with the major division corresponding to MGE origin (Pvalb, Sst) versus CGE origin (Lamp5, Sncg, Serpinf1, Vip).",
    "title": null,
    "cite_key": "Tasic2018",
    "evidence": "23,822 cells from mouse primary visual cortex (VISp) and anterior lateral motor cortex (ALM); 133 transcriptomic types defined by scRNA-seq.",
    "effect_size": "6 GABAergic subclasses + 2 distinct types; nearly all GABA types shared across V1 and ALM (vs. glutamatergic types mostly area-specific)",
    "figure_data": [
      {
        "type": "cell_type_count",
        "unit": "subclasses",
        "value": 6,
        "metric": "GABAergic transcriptomic subclasses",
        "source": "Fig. 1c",
        "context": "Plus 2 distinct types (Sst-Chodl, Meis2-Adamts19)"
      }
    ],
    "text_access": "fulltext",
    "study_system": "mouse, V1 and ALM cortex (adult)",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "primary",
    "_source_cluster_index": 80,
    "claim_source_sentence": "GABAergic cell type taxonomy by scRNA-seq We define six subclasses of GABAergic cells: Sst, Pvalb, Vip , Lamp5, Sncg and Serpinf1 , and two distinct types: Sst-Chodl and Meis2-Adamts19 ( Fig. 1c ). The major division among GABAergic types largely corresponds to their developmental origin in the medial ganglionic eminence ( Pvalb and Sst subclasses) or caudal ganglionic eminence (Lamp5, Sncg, Serpinfl and Vip subclasses).",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Nearly all types of GABA (γ-aminobutyric acid)-containing neurons are shared across both areas, whereas most types of glutamatergic neurons were found in one of the two areas."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "6 GABAergic subclasses + 2 distinct types; nearly all GABA types shared across V1 and ALM (vs. glutamatergic types mostly area-specific)",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-pm-30382198"
  ],
  "source_span": "GABAergic cell type taxonomy by scRNA-seq We define six subclasses of GABAergic cells: Sst, Pvalb, Vip , Lamp5, Sncg and Serpinf1 , and two distinct types: Sst-Chodl and Meis2-Adamts19 ( Fig. 1c ). The major division among GABAergic types largely corresponds to their developmental origin in the medial ganglionic eminence ( Pvalb and Sst subclasses) or caudal ganglionic eminence (Lamp5, Sncg, Serpinfl and Vip subclas...",
  "study_system": "mouse, V1 and ALM cortex (adult)",
  "evidence_refs": [
    {
      "ref": "paper:paper-pm-30382198"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "23,822 cells from mouse primary visual cortex (VISp) and anterior lateral motor cortex (ALM); 133 transcriptomic types defined by scRNA-seq.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "primary",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}