Six transcriptomic subclasses of GABAergic neurons (Sst, Pvalb, Vip, Lamp5, Snc…

Six transcriptomic subclasses of GABAergic neurons (Sst, Pvalb, Vip, Lamp5, Sncg, Serpinf1) plus two distinct types (Sst-Chodl, Meis2-Adamts19) define mouse adult cortical interneuron taxonomy by single-cell RNA-seq, with the major division corresponding to MGE origin (Pvalb, Sst) versus CGE origin (Lamp5, Sncg, Serpinf1, Vip).

{
  "n": 23822,
  "doi": "10.1038/s41586-018-0654-5",
  "claim": "Six transcriptomic subclasses of GABAergic neurons (Sst, Pvalb, Vip, Lamp5, Sncg, Serpinf1) plus two distinct types (Sst-Chodl, Meis2-Adamts19) define mouse adult cortical interneuron taxonomy by single-cell RNA-seq, with the major division corresponding to MGE origin (Pvalb, Sst) versus CGE origin (Lamp5, Sncg, Serpinf1, Vip).",
  "title": null,
  "cite_key": "Tasic2018",
  "evidence": "23,822 cells from mouse primary visual cortex (VISp) and anterior lateral motor cortex (ALM); 133 transcriptomic types defined by scRNA-seq.",
  "effect_size": "6 GABAergic subclasses + 2 distinct types; nearly all GABA types shared across V1 and ALM (vs. glutamatergic types mostly area-specific)",
  "figure_data": [
    {
      "type": "cell_type_count",
      "unit": "subclasses",
      "value": 6,
      "metric": "GABAergic transcriptomic subclasses",
      "source": "Fig. 1c",
      "context": "Plus 2 distinct types (Sst-Chodl, Meis2-Adamts19)"
    }
  ],
  "text_access": "fulltext",
  "study_system": "mouse, V1 and ALM cortex (adult)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "primary",
  "_source_cluster_index": 80,
  "claim_source_sentence": "GABAergic cell type taxonomy by scRNA-seq We define six subclasses of GABAergic cells: Sst, Pvalb, Vip , Lamp5, Sncg and Serpinf1 , and two distinct types: Sst-Chodl and Meis2-Adamts19 ( Fig. 1c ). The major division among GABAergic types largely corresponds to their developmental origin in the medial ganglionic eminence ( Pvalb and Sst subclasses) or caudal ganglionic eminence (Lamp5, Sncg, Serpinfl and Vip subclasses).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Nearly all types of GABA (γ-aminobutyric acid)-containing neurons are shared across both areas, whereas most types of glutamatergic neurons were found in one of the two areas."
}

[
  "paper:paper-pm-30382198"
]

GABAergic cell type taxonomy by scRNA-seq We define six subclasses of GABAergic cells: Sst, Pvalb, Vip , Lamp5, Sncg and Serpinf1 , and two distinct types: Sst-Chodl and Meis2-Adamts19 ( Fig. 1c ). The major division among GABAergic types largely corresponds to their developmental origin in the medial ganglionic eminence ( Pvalb and Sst subclasses) or caudal ganglionic eminence (Lamp5, Sncg, Serpinfl and Vip subclas...

[
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    "ref": "paper:paper-pm-30382198"
  }
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