Version history

{
  "scope": "mouse cortex, Tg(Htr3a-GFP), in utero CGE grafts",
  "claim_text": "Cortical 5-HT3A receptor-expressing interneurons are predominantly generated in the caudal ganglionic eminence; in utero CGE grafts of E14 Htr3a-GFP+ cells reproduce the supragranular laminar distribution and neurochemical profile (VIP, NPY, reelin, calretinin) characteristic of CGE-lineage interneurons.",
  "raw_fields": {
    "n": null,
    "doi": "10.1093/cercor/bhp310",
    "claim": "Cortical 5-HT3A receptor-expressing interneurons are predominantly generated in the caudal ganglionic eminence; in utero CGE grafts of E14 Htr3a-GFP+ cells reproduce the supragranular laminar distribution and neurochemical profile (VIP, NPY, reelin, calretinin) characteristic of CGE-lineage interneurons.",
    "title": null,
    "cite_key": "Vucurovic2010",
    "evidence": "Body, Results: Tg(Htr3a-GFP) mouse line, in utero grafts of CGE vs AEP/POA explants, immunohistochemistry, and patch-clamp recordings.",
    "effect_size": "In Htr3a-GFP+ NPY cluster: 52% reelin+; in VIP cluster: 23% reelin+",
    "figure_data": [
      {
        "type": "marker_co-expression",
        "unit": "percent",
        "value": 52,
        "metric": "% reelin+ in Htr3a-GFP NPY cluster",
        "source": "Lee 2010 quantification",
        "context": "5HT3aR-GFP+ NPY-cluster CGE-derived interneurons in mouse cortex"
      },
      {
        "type": "marker_co-expression",
        "unit": "percent",
        "value": 23,
        "metric": "% reelin+ in Htr3a-GFP VIP cluster",
        "source": "Lee 2010 quantification",
        "context": "5HT3aR-GFP+ VIP-cluster CGE-derived interneurons in mouse cortex"
      }
    ],
    "text_access": "fulltext",
    "study_system": "mouse cortex, Tg(Htr3a-GFP), in utero CGE grafts",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "replicated",
    "_source_cluster_index": 10,
    "claim_source_sentence": "Various techniques including homochronic in utero grafts performed at the peak of genesis of cortical 5-HT 3A + interneurons revealed that these neurons are mainly generated in the CGE.",
    "replication_evidence_dois": [
      "10.1523/jneurosci.4515-09.2010",
      "10.1523/jneurosci.1869-10.2010"
    ],
    "effect_size_source_sentence": "Interestingly, Reelin was expressed in 52% of cells in the NPY-cluster, whereas only 23% of cells of the VIP-cluster contained this marker."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "In Htr3a-GFP+ NPY cluster: 52% reelin+; in VIP cluster: 23% reelin+",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-0336a131683f"
  ],
  "source_span": "Various techniques including homochronic in utero grafts performed at the peak of genesis of cortical 5-HT 3A + interneurons revealed that these neurons are mainly generated in the CGE.",
  "study_system": "mouse cortex, Tg(Htr3a-GFP), in utero CGE grafts",
  "evidence_refs": [
    {
      "ref": "paper:paper-0336a131683f"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Body, Results: Tg(Htr3a-GFP) mouse line, in utero grafts of CGE vs AEP/POA explants, immunohistochemistry, and patch-clamp recordings.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}