- raw_fields
{
"n": 0,
"doi": "10.1523/JNEUROSCI.4565-14.2015",
"claim": "Mediodorsal thalamus drives feedforward inhibition in the anterior cingulate cortex via PV interneurons, with PV-mediated feedforward inhibition limiting the temporal integration window for pyramidal neuron firing",
"evidence": "Optogenetic stimulation of MD thalamic inputs with patch-clamp recordings in dACC slices",
"effect_size": "Feedforward inhibition limits temporal integration window with greater flexibility than sensory cortex",
"text_access": "fulltext",
"study_system": "mouse anterior cingulate cortex, in vitro optogenetics",
"replication_status": "single study",
"claim_source_sentence": "We demonstrate that axons arising from MD neurons directly synapse onto and excite PV interneurons that in turn mediate feedforward inhibition of pyramidal neurons in layer 3 of the dACC. This feedforward inhibition in the dACC limits the time window during which pyramidal neurons integrate excitatory synaptic inputs and fire action potentials, but in a manner that allows for greater flexibility than in sensory cortex.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "This feedforward inhibition in the dACC limits the time window during which pyramidal neurons integrate excitatory synaptic inputs and fire action potentials, but in a manner that allows for greater flexibility than in sensory cortex."
}- source_refs
[
"paper:paper-86169cad4277"
]
- source_span
We demonstrate that axons arising from MD neurons directly synapse onto and excite PV interneurons that in turn mediate feedforward inhibition of pyramidal neurons in layer 3 of the dACC. This feedforward inhibition in the dACC limits the time window during which pyramidal neurons integrate excitatory synaptic inputs and fire action potentials, but in a manner that allows for greater flexibility than in sensory cort...
- evidence_refs
[
{
"ref": "paper:paper-86169cad4277"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}