Version history

{
  "scope": "mouse anterior cingulate cortex, in vitro optogenetics",
  "claim_text": "Mediodorsal thalamus drives feedforward inhibition in the anterior cingulate cortex via PV interneurons, with PV-mediated feedforward inhibition limiting the temporal integration window for pyramidal neuron firing",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/JNEUROSCI.4565-14.2015",
    "claim": "Mediodorsal thalamus drives feedforward inhibition in the anterior cingulate cortex via PV interneurons, with PV-mediated feedforward inhibition limiting the temporal integration window for pyramidal neuron firing",
    "evidence": "Optogenetic stimulation of MD thalamic inputs with patch-clamp recordings in dACC slices",
    "effect_size": "Feedforward inhibition limits temporal integration window with greater flexibility than sensory cortex",
    "text_access": "fulltext",
    "study_system": "mouse anterior cingulate cortex, in vitro optogenetics",
    "replication_status": "single study",
    "claim_source_sentence": "We demonstrate that axons arising from MD neurons directly synapse onto and excite PV interneurons that in turn mediate feedforward inhibition of pyramidal neurons in layer 3 of the dACC. This feedforward inhibition in the dACC limits the time window during which pyramidal neurons integrate excitatory synaptic inputs and fire action potentials, but in a manner that allows for greater flexibility than in sensory cortex.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "This feedforward inhibition in the dACC limits the time window during which pyramidal neurons integrate excitatory synaptic inputs and fire action potentials, but in a manner that allows for greater flexibility than in sensory cortex."
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "effect_size": "Feedforward inhibition limits temporal integration window with greater flexibility than sensory cortex",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-86169cad4277"
  ],
  "source_span": "We demonstrate that axons arising from MD neurons directly synapse onto and excite PV interneurons that in turn mediate feedforward inhibition of pyramidal neurons in layer 3 of the dACC. This feedforward inhibition in the dACC limits the time window during which pyramidal neurons integrate excitatory synaptic inputs and fire action potentials, but in a manner that allows for greater flexibility than in sensory cort...",
  "study_system": "mouse anterior cingulate cortex, in vitro optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-86169cad4277"
    }
  ],
  "section_title": "Local Circuit Motifs: Perisomatic Inhibition, Feedback, and Feedforward",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Optogenetic stimulation of MD thalamic inputs with patch-clamp recordings in dACC slices",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "single study",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}