VIP neurons in mouse V1 have unusually high spontaneous baseline firing rates c…

VIP neurons in mouse V1 have unusually high spontaneous baseline firing rates compared to SST and pyramidal neurons; this elevated baseline is the substrate that allows the high-contrast suppression below baseline, and lets the cortical circuit *bidirectionally* modulate pyramidal-cell disinhibition (raise OR lower) depending on stimulus contrast.

{
  "n": null,
  "doi": "10.7554/elife.55130",
  "claim": "VIP neurons in mouse V1 have unusually high spontaneous baseline firing rates compared to SST and pyramidal neurons; this elevated baseline is the substrate that allows the high-contrast suppression below baseline, and lets the cortical circuit *bidirectionally* modulate pyramidal-cell disinhibition (raise OR lower) depending on stimulus contrast.",
  "title": null,
  "cite_key": "Millman2020",
  "evidence": "2P imaging (Lee 2020 eLife)",
  "effect_size": "qualitative — VIP baseline > SST/Pyr",
  "text_access": "fulltext",
  "study_system": "awake mouse V1",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 80,
  "claim_source_sentence": "Our measurements of contrast tuning suggest that the high spontaneous activity of VIP neurons enables the cortical circuit to raise or lower the amount of disinhibition of pyramidal neurons depending on stimulus contrast.",
  "replication_evidence_dois": [
    "10.1152/jn.01124.2015"
  ],
  "effect_size_source_sentence": "the high spontaneous activity of VIP neurons that is available to be suppressed compared to the other neuron types measured here."
}

[
  "paper:paper-f2c584233c97"
]

[
  {
    "ref": "paper:paper-f2c584233c97"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}