Version history

{
  "scope": "Mouse cortex (V1, ALM, somatosensory), awake/anesthetized, multiple Cre lines; in vivo extracellular recording",
  "claim_text": "Optogenetic photoinhibition in mouse cortex spreads through recurrent excitatory connectivity: exciting GABAergic interneurons paradoxically suppresses both excitatory and inhibitory cells via withdrawal of recurrent excitation, evidence that the network operates in the ISN regime with strong E→E coupling.",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.48622",
    "claim": "Optogenetic photoinhibition in mouse cortex spreads through recurrent excitatory connectivity: exciting GABAergic interneurons paradoxically suppresses both excitatory and inhibitory cells via withdrawal of recurrent excitation, evidence that the network operates in the ISN regime with strong E→E coupling.",
    "cite_key": "Li2019",
    "evidence": "Extracellular recording in mouse cortex during optogenetic photoinhibition using VGAT-ChR2, PV-Cre × Ai32, PV-Cre × ReaChR, and SST-Cre × Ai32 lines; characterization of spatiotemporal spread, paradoxical effects, and rebound.",
    "effect_size": "qualitative — rebound activity decayed to baseline over hundreds of milliseconds; paradoxical decreases in subset of FS neurons in VGAT-ChR2 line",
    "text_access": "fulltext",
    "study_system": "Mouse cortex (V1, ALM, somatosensory), awake/anesthetized, multiple Cre lines; in vivo extracellular recording",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Because of recurrent excitatory connectivity in cortical circuits, the effects on excitatory neuron spike rates are amplified, which causes a large reduction in excitation of inhibitory interneurons.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.7554/eLife.54875",
      "10.7554/eLife.49967"
    ],
    "effect_size_source_sentence": "Removal of photoinhibition elevated spike rate above baseline ('rebound activity'), which decayed to baseline over hundreds of milliseconds ()."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "qualitative — rebound activity decayed to baseline over hundreds of milliseconds; paradoxical decreases in subset of FS neurons in VGAT-ChR2 line",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:e0c6b75e-bb8d-471f-88d3-e00e2a65ed4d"
  ],
  "source_span": "Because of recurrent excitatory connectivity in cortical circuits, the effects on excitatory neuron spike rates are amplified, which causes a large reduction in excitation of inhibitory interneurons.",
  "study_system": "Mouse cortex (V1, ALM, somatosensory), awake/anesthetized, multiple Cre lines; in vivo extracellular recording",
  "evidence_refs": [
    {
      "ref": "paper:e0c6b75e-bb8d-471f-88d3-e00e2a65ed4d"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Extracellular recording in mouse cortex during optogenetic photoinhibition using VGAT-ChR2, PV-Cre × Ai32, PV-Cre × ReaChR, and SST-Cre × Ai32 lines; characterization of spatiotemporal spread, paradoxical effects, and rebound.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}