Details
- scope
- Mouse cortex (V1, ALM, somatosensory), awake/anesthetized, multiple Cre lines; in vivo extracellular recording
- section_id
- section_09
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
- effect_size
- qualitative — rebound activity decayed to baseline over hundreds of milliseconds; paradoxical decreases in subset of FS neurons in VGAT-ChR2 line
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-09-amplification-isn
- source_kind
- review_finding
- source_path
- evidence/section_09_evidence_package.json
- source_span
- Because of recurrent excitatory connectivity in cortical circuits, the effects on excitatory neuron spike rates are amplified, which causes a large reduction in excitation of inhibitory interneurons.
- study_system
- Mouse cortex (V1, ALM, somatosensory), awake/anesthetized, multiple Cre lines; in vivo extracellular recording
- section_title
- 9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation
- evidence_summary
- Extracellular recording in mouse cortex during optogenetic photoinhibition using VGAT-ChR2, PV-Cre × Ai32, PV-Cre × ReaChR, and SST-Cre × Ai32 lines; characterization of spatiotemporal spread, paradoxical effects, and rebound.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-09-amplification-isn
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
- claim_text
Optogenetic photoinhibition in mouse cortex spreads through recurrent excitatory connectivity: exciting GABAergic interneurons paradoxically suppresses both excitatory and inhibitory cells via withdrawal of recurrent excitation, evidence that the network operates in the ISN regime with strong E→E coupling.
- raw_fields
{ "n": 0, "doi": "10.7554/elife.48622", "claim": "Optogenetic photoinhibition in mouse cortex spreads through recurrent excitatory connectivity: exciting GABAergic interneurons paradoxically suppresses both excitatory and inhibitory cells via withdrawal of recurrent excitation, evidence that the network operates in the ISN regime with strong E→E coupling.", "cite_key": "Li2019", "evidence": "Extracellular recording in mouse cortex during optogenetic photoinhibition using VGAT-ChR2, PV-Cre × Ai32, PV-Cre × ReaChR, and SST-Cre × Ai32 lines; characterization of spatiotemporal spread, paradoxical effects, and rebound.", "effect_size": "qualitative — rebound activity decayed to baseline over hundreds of milliseconds; paradoxical decreases in subset of FS neurons in VGAT-ChR2 line", "text_access": "fulltext", "study_system": "Mouse cortex (V1, ALM, somatosensory), awake/anesthetized, multiple Cre lines; in vivo extracellular recording", "argument_role": "supporting", "replication_status": "independently_replicated", "claim_source_sentence": "Because of recurrent excitatory connectivity in cortical circuits, the effects on excitatory neuron spike rates are amplified, which causes a large reduction in excitation of inhibitory interneurons.", "source_provenance_status": "ok", "replication_evidence_dois": [ "10.7554/eLife.54875", "10.7554/eLife.49967" ], "effect_size_source_sentence": "Removal of photoinhibition elevated spike rate above baseline ('rebound activity'), which decayed to baseline over hundreds of milliseconds ()." }- source_refs
[ "paper:e0c6b75e-bb8d-471f-88d3-e00e2a65ed4d" ]
- evidence_refs
[ { "ref": "paper:e0c6b75e-bb8d-471f-88d3-e00e2a65ed4d" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }