Version history

{
  "scope": "rat neostriatum, juvenile (P16-20)",
  "claim_text": "Fast-spiking cells were originally defined physiologically by very short-duration action potentials, short-duration afterhyperpolarizations, constant spike frequency during depolarizing current pulses, more negative resting potentials, and lower input resistance, and were immunoreactive for parvalbumin.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.13-11-04908.1993",
    "claim": "Fast-spiking cells were originally defined physiologically by very short-duration action potentials, short-duration afterhyperpolarizations, constant spike frequency during depolarizing current pulses, more negative resting potentials, and lower input resistance, and were immunoreactive for parvalbumin.",
    "evidence": "Whole-cell recordings in rat neostriatal slices with biocytin staining and immunocytochemistry identified 3 classes of interneurons. FS cells were parvalbumin+ and GABAergic with two morphological subtypes.",
    "effect_size": "3 interneuron classes: FS (PV+), PLTS (NOS+), and LA cells; FS cells with two morphological subtypes",
    "text_access": "abstract_only",
    "study_system": "rat neostriatum, juvenile (P16-20)",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "The first class of interneurons (fast-spiking cells, FS cells) fired very short-duration action potentials with short-duration afterhyperpolarizations at constant spike frequency during depolarizing current pulses. FS cells had more negative resting potentials and lower input resistances than the other two classes.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2016.06.033"
    ],
    "effect_size_source_sentence": "FS cells were immunoreactive for parvalbumin. As all parvalbumin-immunoreactive cells in the neostriatum were also immunoreactive for GABA, FS cells were considered to be GABAergic."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "3 interneuron classes: FS (PV+), PLTS (NOS+), and LA cells; FS cells with two morphological subtypes",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-3522fd039446"
  ],
  "source_span": "The first class of interneurons (fast-spiking cells, FS cells) fired very short-duration action potentials with short-duration afterhyperpolarizations at constant spike frequency during depolarizing current pulses. FS cells had more negative resting potentials and lower input resistances than the other two classes.",
  "study_system": "rat neostriatum, juvenile (P16-20)",
  "evidence_refs": [
    {
      "ref": "paper:paper-3522fd039446"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Whole-cell recordings in rat neostriatal slices with biocytin staining and immunocytochemistry identified 3 classes of interneurons. FS cells were parvalbumin+ and GABAergic with two morphological subtypes.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}