- claim_text
Fast-spiking cells were originally defined physiologically by very short-duration action potentials, short-duration afterhyperpolarizations, constant spike frequency during depolarizing current pulses, more negative resting potentials, and lower input resistance, and were immunoreactive for parvalbumin.
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.13-11-04908.1993",
"claim": "Fast-spiking cells were originally defined physiologically by very short-duration action potentials, short-duration afterhyperpolarizations, constant spike frequency during depolarizing current pulses, more negative resting potentials, and lower input resistance, and were immunoreactive for parvalbumin.",
"evidence": "Whole-cell recordings in rat neostriatal slices with biocytin staining and immunocytochemistry identified 3 classes of interneurons. FS cells were parvalbumin+ and GABAergic with two morphological subtypes.",
"effect_size": "3 interneuron classes: FS (PV+), PLTS (NOS+), and LA cells; FS cells with two morphological subtypes",
"text_access": "abstract_only",
"study_system": "rat neostriatum, juvenile (P16-20)",
"replication_status": "independently_replicated",
"claim_source_sentence": "The first class of interneurons (fast-spiking cells, FS cells) fired very short-duration action potentials with short-duration afterhyperpolarizations at constant spike frequency during depolarizing current pulses. FS cells had more negative resting potentials and lower input resistances than the other two classes.",
"replication_evidence_dois": [
"10.1016/j.neuron.2016.06.033"
],
"effect_size_source_sentence": "FS cells were immunoreactive for parvalbumin. As all parvalbumin-immunoreactive cells in the neostriatum were also immunoreactive for GABA, FS cells were considered to be GABAergic."
}- source_refs
[
"paper:paper-3522fd039446"
]
- source_span
The first class of interneurons (fast-spiking cells, FS cells) fired very short-duration action potentials with short-duration afterhyperpolarizations at constant spike frequency during depolarizing current pulses. FS cells had more negative resting potentials and lower input resistances than the other two classes.
- evidence_refs
[
{
"ref": "paper:paper-3522fd039446"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}