Version history

{
  "scope": "Mouse brain in vivo; ULTRA wide-field adaptive 2P microscope",
  "claim_text": "ULTRA, a wide-field adaptive 2P microscope, images mouse cortex at single-cell resolution across a >50 mm² FOV from surface down to 900 µm — pushing the present-day in-vivo 2P recording envelope toward but not into deeper cortical layers.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41377-026-02252-2",
    "claim": "ULTRA, a wide-field adaptive 2P microscope, images mouse cortex at single-cell resolution across a >50 mm² FOV from surface down to 900 µm — pushing the present-day in-vivo 2P recording envelope toward but not into deeper cortical layers.",
    "cite_key": "Yang2026a",
    "evidence": "Quantitative bound on combined-depth-and-FOV 2P imaging in mouse cortex; complements three-photon depth claims by showing 2P stops short of ~1 mm.",
    "effect_size": ">50 mm² FOV; depth up to 900 µm; volume 45.24 mm³",
    "text_access": "abstract_only",
    "study_system": "Mouse brain in vivo; ULTRA wide-field adaptive 2P microscope",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "To demonstrate its capabilities, we conducted a series of experiments under multiple imaging conditions, successfully visualizing brain structures and neuronal activities spanning a spatial range of over 7 mm from superficial layers to depths of up to 900 μm, while covering a volume of 45.24 mm<sup>3</sup> in the mouse brain.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Here, we introduce a state-of-the-art two-photon microscopy system, ULTRA, capable of single-cell resolution imaging across an ultra-large field of view (FOV) exceeding 50 mm², enabling deep and wide field in vivo imaging."
  },
  "section_id": "section_15",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json",
  "effect_size": ">50 mm² FOV; depth up to 900 µm; volume 45.24 mm³",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits",
  "source_kind": "review_finding",
  "source_path": "evidence/section_15_evidence_package.json",
  "source_refs": [
    "paper:paper-fa8bc7d8660d"
  ],
  "source_span": "To demonstrate its capabilities, we conducted a series of experiments under multiple imaging conditions, successfully visualizing brain structures and neuronal activities spanning a spatial range of over 7 mm from superficial layers to depths of up to 900 μm, while covering a volume of 45.24 mm<sup>3</sup> in the mouse brain.",
  "study_system": "Mouse brain in vivo; ULTRA wide-field adaptive 2P microscope",
  "evidence_refs": [
    {
      "ref": "paper:paper-fa8bc7d8660d"
    }
  ],
  "section_title": "15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Quantitative bound on combined-depth-and-FOV 2P imaging in mouse cortex; complements three-photon depth claims by showing 2P stops short of ~1 mm.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}