Prenatal Valproate Exposure Differentially Affects Parvalbumin-Expressing Neuro…

{
  "n": 0,
  "doi": "10.3389/fnmol.2016.00150",
  "claim": "Prenatal Valproate Exposure Differentially Affects Parvalbumin-Expressing Neurons and Related Circuits in the Cortex and Striatum of Mice",
  "evidence": "Autism spectrum disorders (ASD) comprise a number of heterogeneous neurodevelopmental diseases characterized by core behavioral symptoms in the domains of social interaction, language/communication an",
  "effect_size": "15%",
  "text_access": "abstract_only",
  "study_system": "europepmc_q8",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "<i>In utero</i> exposure to valproic acid (VPA) has evolved as a highly recognized rodent ASD model due to the robust behavioral phenotype observed in the offspring and the proven construct-, face- and predictive validity of the model.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "We found a ∼15% reduction in the number of PV<sup>+</sup> cells and decreased <i>Pvalb</i> mRNA and PV protein levels in the striatum of VPA mice compared to controls, while the number of VVA<sup>+</sup> cells was unchanged, indicating that Pvalb neurons were affected at the level of the transcriptome"
}

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]

[
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    "ref": "paper:paper-0ce02cff723e"
  }
]

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
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