- claim_text
Prenatal valproate exposure differentially affects parvalbumin-expressing neurons and related cortical circuits, with implications for understanding how developmental ion channel perturbation alters the maturation of the fast-spiking phenotype.
- raw_fields
{
"n": 0,
"doi": "10.3389/fnmol.2016.00150",
"claim": "Prenatal valproate exposure differentially affects parvalbumin-expressing neurons and related cortical circuits, with implications for understanding how developmental ion channel perturbation alters the maturation of the fast-spiking phenotype.",
"evidence": "Study of how prenatal exposure to an antiepileptic drug (valproate) that modifies ion channel function specifically impacts PV neuron development.",
"effect_size": "differential effects on PV neurons vs other interneuron types after prenatal valproate",
"text_access": "abstract_only",
"study_system": "mouse cortex, prenatal valproate exposure model",
"replication_status": "replication_unknown",
"claim_source_sentence": "Prenatal Valproate Exposure Differentially Affects Parvalbumin-Expressing Neurons and Related Cortical Circuits.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Prenatal Valproate Exposure Differentially Affects Parvalbumin-Expressing Neurons and Related Cortical Circuits."
}- source_refs
[
"paper:paper-0ce02cff723e"
]
- evidence_refs
[
{
"ref": "paper:paper-0ce02cff723e"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}