Version history

{
  "scope": "mouse neocortical slices, in vitro",
  "claim_text": "GABA release from fast-spiking cells is robustly inhibited by muscarinic, serotonin, adenosine, and GABAB receptors, and muscarinic inhibition of FS cell GABA release suppresses thalamocortical feedforward inhibition to promote thalamocortical excitation",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2008.04.024",
    "claim": "GABA release from fast-spiking cells is robustly inhibited by muscarinic, serotonin, adenosine, and GABAB receptors, and muscarinic inhibition of FS cell GABA release suppresses thalamocortical feedforward inhibition to promote thalamocortical excitation",
    "evidence": "Paired recordings in neocortical slices with pharmacological manipulation of neuromodulatory receptors",
    "effect_size": "Muscarinic suppression of FS GABA release plus nicotinic enhancement of thalamic input promotes thalamocortical excitation",
    "text_access": "fulltext",
    "study_system": "mouse neocortical slices, in vitro",
    "replication_status": "within-lab",
    "claim_source_sentence": "GABA release from fast-spiking (FS) cells, the most prevalent interneuron subtype in neocortex, is robustly inhibited following activation of muscarinic, serotonin, adenosine, and GABA B receptors—an effect that regulates FS cell control of excitatory neuron firing. The potent muscarinic inhibition of GABA release from FS cells suppresses thalamocortical feedforward inhibition.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "This is supplemented by the muscarinic-mediated depolarization of thalamo-recipient excitatory neurons and the nicotinic enhancement of thalamic input onto these neurons to promote thalamocortical excitation."
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "effect_size": "Muscarinic suppression of FS GABA release plus nicotinic enhancement of thalamic input promotes thalamocortical excitation",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-c642a8c68cfb"
  ],
  "source_span": "GABA release from fast-spiking (FS) cells, the most prevalent interneuron subtype in neocortex, is robustly inhibited following activation of muscarinic, serotonin, adenosine, and GABA B receptors—an effect that regulates FS cell control of excitatory neuron firing. The potent muscarinic inhibition of GABA release from FS cells suppresses thalamocortical feedforward inhibition.",
  "study_system": "mouse neocortical slices, in vitro",
  "evidence_refs": [
    {
      "ref": "paper:paper-c642a8c68cfb"
    }
  ],
  "section_title": "Local Circuit Motifs: Perisomatic Inhibition, Feedback, and Feedforward",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Paired recordings in neocortical slices with pharmacological manipulation of neuromodulatory receptors",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "within-lab",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}