- claim_text
GABA release from fast-spiking cells is robustly inhibited by muscarinic, serotonin, adenosine, and GABAB receptors, and muscarinic inhibition of FS cell GABA release suppresses thalamocortical feedforward inhibition to promote thalamocortical excitation
- raw_fields
{
"n": 0,
"doi": "10.1016/j.neuron.2008.04.024",
"claim": "GABA release from fast-spiking cells is robustly inhibited by muscarinic, serotonin, adenosine, and GABAB receptors, and muscarinic inhibition of FS cell GABA release suppresses thalamocortical feedforward inhibition to promote thalamocortical excitation",
"evidence": "Paired recordings in neocortical slices with pharmacological manipulation of neuromodulatory receptors",
"effect_size": "Muscarinic suppression of FS GABA release plus nicotinic enhancement of thalamic input promotes thalamocortical excitation",
"text_access": "fulltext",
"study_system": "mouse neocortical slices, in vitro",
"replication_status": "within-lab",
"claim_source_sentence": "GABA release from fast-spiking (FS) cells, the most prevalent interneuron subtype in neocortex, is robustly inhibited following activation of muscarinic, serotonin, adenosine, and GABA B receptors—an effect that regulates FS cell control of excitatory neuron firing. The potent muscarinic inhibition of GABA release from FS cells suppresses thalamocortical feedforward inhibition.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "This is supplemented by the muscarinic-mediated depolarization of thalamo-recipient excitatory neurons and the nicotinic enhancement of thalamic input onto these neurons to promote thalamocortical excitation."
}- source_refs
[
"paper:paper-c642a8c68cfb"
]
- source_span
GABA release from fast-spiking (FS) cells, the most prevalent interneuron subtype in neocortex, is robustly inhibited following activation of muscarinic, serotonin, adenosine, and GABA B receptors—an effect that regulates FS cell control of excitatory neuron firing. The potent muscarinic inhibition of GABA release from FS cells suppresses thalamocortical feedforward inhibition.
- evidence_refs
[
{
"ref": "paper:paper-c642a8c68cfb"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}