In mouse motor cortex, L2/3 excitatory inputs to L5B pyramidal neurons are high…

In mouse motor cortex, L2/3 excitatory inputs to L5B pyramidal neurons are highly specific by both sub-layer position and projection target: upper-L5B corticospinal neurons receive strong L2/3 input while neighboring upper-L5B corticostriatal neurons receive ~10-fold weaker input, despite L2/3 axons projecting throughout upper L5B.

{
  "n": 0,
  "doi": "10.1038/nn.2538",
  "claim": "In mouse motor cortex, L2/3 excitatory inputs to L5B pyramidal neurons are highly specific by both sub-layer position and projection target: upper-L5B corticospinal neurons receive strong L2/3 input while neighboring upper-L5B corticostriatal neurons receive ~10-fold weaker input, despite L2/3 axons projecting throughout upper L5B.",
  "cite_key": "Anderson2010",
  "evidence": "Glutamate-uncaging laser-scanning photostimulation (LSPS) input mapping onto retrogradely-bead-labeled corticospinal and corticostriatal L5B neurons in mouse motor-frontal cortex coronal slices.",
  "effect_size": "~10-fold difference in L2/3→upper-L5B input strength between corticospinal and corticostriatal targets",
  "text_access": "fulltext",
  "study_system": "mouse motor-frontal cortex, L5B retrogradely-labeled corticospinal and corticostriatal neurons",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "connectivity was incongruously low for upper-5B corticostriatal neurons, differing by a factor of ~10 compared to neighboring upper-5B corticospinal neurons",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1371/journal.pbio.1000572",
    "10.3389/neuro.04.006.2008"
  ],
  "effect_size_source_sentence": "differing by a factor of ~10 compared to neighboring upper-5B corticospinal neurons"
}

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