Version history

{
  "scope": "mouse motor-frontal cortex, L5B retrogradely-labeled corticospinal and corticostriatal neurons",
  "claim_text": "In mouse motor cortex, L2/3 excitatory inputs to L5B pyramidal neurons are highly specific by both sub-layer position and projection target: upper-L5B corticospinal neurons receive strong L2/3 input while neighboring upper-L5B corticostriatal neurons receive ~10-fold weaker input, despite L2/3 axons projecting throughout upper L5B.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nn.2538",
    "claim": "In mouse motor cortex, L2/3 excitatory inputs to L5B pyramidal neurons are highly specific by both sub-layer position and projection target: upper-L5B corticospinal neurons receive strong L2/3 input while neighboring upper-L5B corticostriatal neurons receive ~10-fold weaker input, despite L2/3 axons projecting throughout upper L5B.",
    "cite_key": "Anderson2010",
    "evidence": "Glutamate-uncaging laser-scanning photostimulation (LSPS) input mapping onto retrogradely-bead-labeled corticospinal and corticostriatal L5B neurons in mouse motor-frontal cortex coronal slices.",
    "effect_size": "~10-fold difference in L2/3→upper-L5B input strength between corticospinal and corticostriatal targets",
    "text_access": "fulltext",
    "study_system": "mouse motor-frontal cortex, L5B retrogradely-labeled corticospinal and corticostriatal neurons",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "connectivity was incongruously low for upper-5B corticostriatal neurons, differing by a factor of ~10 compared to neighboring upper-5B corticospinal neurons",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1371/journal.pbio.1000572",
      "10.3389/neuro.04.006.2008"
    ],
    "effect_size_source_sentence": "differing by a factor of ~10 compared to neighboring upper-5B corticospinal neurons"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "~10-fold difference in L2/3→upper-L5B input strength between corticospinal and corticostriatal targets",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-e4f11964cdc5"
  ],
  "source_span": "connectivity was incongruously low for upper-5B corticostriatal neurons, differing by a factor of ~10 compared to neighboring upper-5B corticospinal neurons",
  "study_system": "mouse motor-frontal cortex, L5B retrogradely-labeled corticospinal and corticostriatal neurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-e4f11964cdc5"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Glutamate-uncaging laser-scanning photostimulation (LSPS) input mapping onto retrogradely-bead-labeled corticospinal and corticostriatal L5B neurons in mouse motor-frontal cortex coronal slices.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}