Version history

{
  "scope": "Mouse secondary motor cortex (M2); MouseLight reconstructions + slice recordings + Cre-line tracing.",
  "claim_text": "In mouse secondary motor cortex (M2), upper layer 5a IT cells that project to other cortical areas' layer 1 form a distinct subclass with broader cortico-cortical targets, larger striatal innervation and characteristic ER81/ETV1 genetic and electrophysiological profile compared to other L5 IT cells.",
  "raw_fields": {
    "n": null,
    "doi": "10.1093/cercor/bhac052",
    "claim": "In mouse secondary motor cortex (M2), upper layer 5a IT cells that project to other cortical areas' layer 1 form a distinct subclass with broader cortico-cortical targets, larger striatal innervation and characteristic ER81/ETV1 genetic and electrophysiological profile compared to other L5 IT cells.",
    "cite_key": "Im2022",
    "evidence": "MouseLight single-neuron reconstructions + experimental Cre-line dissection of L5a vs L5b IT cells in mouse M2; ER81 (ETV1) genetic profiling and electrophysiology.",
    "effect_size": "L5a ER81+ IT cells in M2 project to L1 of more cortical areas and innervate more striatal volume than other L5 IT cells.",
    "text_access": "fulltext",
    "study_system": "Mouse secondary motor cortex (M2); MouseLight reconstructions + slice recordings + Cre-line tracing.",
    "argument_role": "supporting",
    "replication_status": "not_yet",
    "claim_source_sentence": "An analysis of the MouseLight database found that L5 IT cells preferentially targeting L1 project broadly to more cortical regions, including the perirhinal and auditory cortices, and innervate a larger volume of striatum than the other L5 IT cells.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "We found experimentally that in upper L5 (L5a), ER81 (ETV1) was found more often in IT cells projecting to L1."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "L5a ER81+ IT cells in M2 project to L1 of more cortical areas and innervate more striatal volume than other L5 IT cells.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-e55711a2961a"
  ],
  "source_span": "An analysis of the MouseLight database found that L5 IT cells preferentially targeting L1 project broadly to more cortical regions, including the perirhinal and auditory cortices, and innervate a larger volume of striatum than the other L5 IT cells.",
  "study_system": "Mouse secondary motor cortex (M2); MouseLight reconstructions + slice recordings + Cre-line tracing.",
  "evidence_refs": [
    {
      "ref": "paper:paper-e55711a2961a"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "MouseLight single-neuron reconstructions + experimental Cre-line dissection of L5a vs L5b IT cells in mouse M2; ER81 (ETV1) genetic profiling and electrophysiology.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "not_yet",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}