In mouse secondary motor cortex (M2), upper layer 5a IT cells that project to o…

In mouse secondary motor cortex (M2), upper layer 5a IT cells that project to other cortical areas' layer 1 form a distinct subclass with broader cortico-cortical targets, larger striatal innervation and characteristic ER81/ETV1 genetic and electrophysiological profile compared to other L5 IT cells.

{
  "n": null,
  "doi": "10.1093/cercor/bhac052",
  "claim": "In mouse secondary motor cortex (M2), upper layer 5a IT cells that project to other cortical areas' layer 1 form a distinct subclass with broader cortico-cortical targets, larger striatal innervation and characteristic ER81/ETV1 genetic and electrophysiological profile compared to other L5 IT cells.",
  "cite_key": "Im2022",
  "evidence": "MouseLight single-neuron reconstructions + experimental Cre-line dissection of L5a vs L5b IT cells in mouse M2; ER81 (ETV1) genetic profiling and electrophysiology.",
  "effect_size": "L5a ER81+ IT cells in M2 project to L1 of more cortical areas and innervate more striatal volume than other L5 IT cells.",
  "text_access": "fulltext",
  "study_system": "Mouse secondary motor cortex (M2); MouseLight reconstructions + slice recordings + Cre-line tracing.",
  "argument_role": "supporting",
  "replication_status": "not_yet",
  "claim_source_sentence": "An analysis of the MouseLight database found that L5 IT cells preferentially targeting L1 project broadly to more cortical regions, including the perirhinal and auditory cortices, and innervate a larger volume of striatum than the other L5 IT cells.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "We found experimentally that in upper L5 (L5a), ER81 (ETV1) was found more often in IT cells projecting to L1."
}

[
  "paper:paper-e55711a2961a"
]

An analysis of the MouseLight database found that L5 IT cells preferentially targeting L1 project broadly to more cortical regions, including the perirhinal and auditory cortices, and innervate a larger volume of striatum than the other L5 IT cells.

[
  {
    "ref": "paper:paper-e55711a2961a"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}