Thalamocortical synapses onto mouse L5 pyramidal neurons in S1 are biased towar…

Thalamocortical synapses onto mouse L5 pyramidal neurons in S1 are biased toward basal dendrites with a secondary contribution onto proximal apical dendrites in L4, and they are clustered along individual dendritic branches rather than uniformly distributed.

{
  "n": 0,
  "doi": "10.3389/fncir.2013.00177",
  "claim": "Thalamocortical synapses onto mouse L5 pyramidal neurons in S1 are biased toward basal dendrites with a secondary contribution onto proximal apical dendrites in L4, and they are clustered along individual dendritic branches rather than uniformly distributed.",
  "cite_key": "Rah2013",
  "evidence": "Large-scale array tomography of a 1.00 × 0.83 × 0.21 mm^3 volume of mouse S1, with parallel EM validation of L4 TC synapses.",
  "effect_size": "TC synapse nearest-neighbor enrichment within 5–15 µm vs random.",
  "text_access": "abstract_only",
  "study_system": "Mouse somatosensory cortex; large-scale array tomography volume reconstruction; parallel electron microscopy of L4 TC synapses",
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  "replication_status": "single_study",
  "claim_source_sentence": "We found that TC synapses primarily target basal dendrites in layer 5, but also make a considerable input to proximal apical dendrites in L4, consistent with previous work. Our analysis further suggests that TC inputs are biased toward certain branches and, within branches, synapses show significant clustering with an excess of TC synapse nearest neighbors within 5-15 μm compared to a random distribution.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "synapses show significant clustering with an excess of TC synapse nearest neighbors within 5-15 μm compared to a random distribution"
}

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We found that TC synapses primarily target basal dendrites in layer 5, but also make a considerable input to proximal apical dendrites in L4, consistent with previous work. Our analysis further suggests that TC inputs are biased toward certain branches and, within branches, synapses show significant clustering with an excess of TC synapse nearest neighbors within 5-15 μm compared to a random distribution.

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