- claim_text
In mouse somatosensory cortex L2/3 pyramidal neurons, NMDAR-dependent LTP of intracortical synapses elicited by rhythmic whisker stimulation requires co-activation of higher-order POm thalamocortical inputs, gated by VIP interneuron-mediated disinhibition.
- raw_fields
{
"n": 0,
"doi": "10.1016/j.neuron.2018.10.049",
"claim": "In mouse somatosensory cortex L2/3 pyramidal neurons, NMDAR-dependent LTP of intracortical synapses elicited by rhythmic whisker stimulation requires co-activation of higher-order POm thalamocortical inputs, gated by VIP interneuron-mediated disinhibition.",
"cite_key": "Williams2019",
"evidence": "Paired activation of cortical and POm inputs increased VIP and PV interneuron activity, decreased SST activity, and disinhibited L2/3 pyramidal cells; VIP-IN disinhibition was required for LTP induction.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "Mouse somatosensory cortex L2/3 pyramidal neurons (thalamocortical slice)",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "We found that projections from higher-order, posterior medial thalamic complex (POm) are key to eliciting N-methyl-D-aspartate receptor (NMDAR)-dependent LTP of intracortical synapses.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-55f18434021b"
]
- evidence_refs
[
{
"ref": "paper:paper-55f18434021b"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}