Version history

{
  "scope": "whole adult mouse brain; scRNA-seq",
  "claim_text": "Yao et al. (2023) found Slc18a3 and Chat expression in several clusters within the Vip GABAergic subclass of isocortex, but expression at cluster level did not cross thresholds for labeling them cholinergic.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41586-023-06812-z",
    "claim": "Yao et al. (2023) found Slc18a3 and Chat expression in several clusters within the Vip GABAergic subclass of isocortex, but expression at cluster level did not cross thresholds for labeling them cholinergic.",
    "title": null,
    "cite_key": "Yao2023",
    "evidence": "Whole-brain cluster-level marker analysis: Vip-Chat clusters express Chat/Slc18a3 at sub-threshold levels, supporting bipolar VIP-ChAT identity reported in primary visual cortex but with low Chat expression.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "whole adult mouse brain; scRNA-seq",
    "target_section": "section_11",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replicated",
    "_source_cluster_index": 10,
    "claim_source_sentence": "We also found Slc18a3 and Chat expression in several clusters in the Vip GABA subclass in isocortex, but its expression at cluster level did not cross our threshold to label these clusters as cholinergic."
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-02-classification",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:1f98e15e-de06-42f7-9da8-1faa69bba835"
  ],
  "source_span": "We also found Slc18a3 and Chat expression in several clusters in the Vip GABA subclass in isocortex, but its expression at cluster level did not cross our threshold to label these clusters as cholinergic.",
  "study_system": "whole adult mouse brain; scRNA-seq",
  "evidence_refs": [
    {
      "ref": "paper:1f98e15e-de06-42f7-9da8-1faa69bba835"
    }
  ],
  "section_title": "Molecular Identity and Transcriptomic Taxonomy",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Whole-brain cluster-level marker analysis: Vip-Chat clusters express Chat/Slc18a3 at sub-threshold levels, supporting bipolar VIP-ChAT identity reported in primary visual cortex but with low Chat expression.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-02-classification",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}