Yao et al. (2023) found Slc18a3 and Chat expression in several clusters within…

Details

scope: whole adult mouse brain; scRNA-seq
claim_text: Yao et al. (2023) found Slc18a3 and Chat expression in several clusters within the Vip GABAergic subclass of isocortex, but expression at cluster level did not cross thresholds for labeling them cholinergic.
section_id: section_02
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json
review_repo: ComputationalReviewVIP
section_ref: wiki_page:computationalreviewvip-02-classification
source_kind: review_finding
source_path: evidence/section_02_evidence_package.json
source_span: We also found Slc18a3 and Chat expression in several clusters in the Vip GABA subclass in isocortex, but its expression at cluster level did not cross our threshold to label these clusters as cholinergic.
study_system: whole adult mouse brain; scRNA-seq
section_title: Molecular Identity and Transcriptomic Taxonomy
evidence_summary: Whole-brain cluster-level marker analysis: Vip-Chat clusters express Chat/Slc18a3 at sub-threshold levels, supporting bipolar VIP-ChAT identity reported in primary visual cortex but with low Chat expression.
review_bundle_ref: analysis_bundle:ab-2ce40c33e827
replication_status: replicated
review_package_ref: analysis_bundle:ab-2ce40c33e827
source_artifact_ref: wiki_page:computationalreviewvip-02-classification
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json
commit_sha: 95e761177f7d2ec565983d3307c14ec238f9677c
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP

Raw fields (4)

raw_fields

{
  "n": null,
  "doi": "10.1038/s41586-023-06812-z",
  "claim": "Yao et al. (2023) found Slc18a3 and Chat expression in several clusters within the Vip GABAergic subclass of isocortex, but expression at cluster level did not cross thresholds for labeling them cholinergic.",
  "title": null,
  "cite_key": "Yao2023",
  "evidence": "Whole-brain cluster-level marker analysis: Vip-Chat clusters express Chat/Slc18a3 at sub-threshold levels, supporting bipolar VIP-ChAT identity reported in primary visual cortex but with low Chat expression.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "whole adult mouse brain; scRNA-seq",
  "target_section": "section_11",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replicated",
  "_source_cluster_index": 10,
  "claim_source_sentence": "We also found Slc18a3 and Chat expression in several clusters in the Vip GABA subclass in isocortex, but its expression at cluster level did not cross our threshold to label these clusters as cholinergic."
}

source_refs

[
  "paper:1f98e15e-de06-42f7-9da8-1faa69bba835"
]

evidence_refs

[
  {
    "ref": "paper:1f98e15e-de06-42f7-9da8-1faa69bba835"
  }
]

source_policy

{
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

Yao et al. (2023) found Slc18a3 and Chat expression in several clusters within…

Details

Replication

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