Version history

{
  "scope": "awake mouse ACx + mPFC; Vip-Cre + ChR2 + extracellular recording",
  "claim_text": "VIP interneurons in awake auditory cortex and mPFC receive strong, brief excitatory drive from reinforcement signals — both punishment (air-puff) and reward — eliciting abrupt firing-rate increases that occur after punishment delivery, with reward producing slower more sustained responses; this temporal pattern is consistent with VIP+ cells acting as a behavioral-event gate for cortical disinhibition.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nature12676",
    "claim": "VIP interneurons in awake auditory cortex and mPFC receive strong, brief excitatory drive from reinforcement signals — both punishment (air-puff) and reward — eliciting abrupt firing-rate increases that occur after punishment delivery, with reward producing slower more sustained responses; this temporal pattern is consistent with VIP+ cells acting as a behavioral-event gate for cortical disinhibition.",
    "title": null,
    "cite_key": "Pi2013",
    "evidence": "in vivo single-unit + optogenetics in awake mouse ACx and mPFC; Pi 2013 Nature",
    "effect_size": "9/10 VIP neurons reward-responsive; punishment-driven response abrupt; ~20% of cortical neurons modulated by VIP optostimulation",
    "text_access": "fulltext",
    "study_system": "awake mouse ACx + mPFC; Vip-Cre + ChR2 + extracellular recording",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 68,
    "claim_source_sentence": "Water reward tended to generate somewhat weaker and more sustained firing rate increases (9/10 VIP neurons, half maximum duration 1.2s).",
    "replication_evidence_dois": [
      "10.1038/nn.4002"
    ],
    "effect_size_source_sentence": "Brief light stimulation of this sparse population of VIP-expressing interneurons (1–2% of cortical neurons) resulted in a disproportionately broad effect, generating significant firing rate changes in ~20% of cortical cells (ACx: 130/495, mPFC: 26/155)."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "9/10 VIP neurons reward-responsive; punishment-driven response abrupt; ~20% of cortical neurons modulated by VIP optostimulation",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-065a0eae69a5"
  ],
  "source_span": "Water reward tended to generate somewhat weaker and more sustained firing rate increases (9/10 VIP neurons, half maximum duration 1.2s).",
  "study_system": "awake mouse ACx + mPFC; Vip-Cre + ChR2 + extracellular recording",
  "evidence_refs": [
    {
      "ref": "paper:paper-065a0eae69a5"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "in vivo single-unit + optogenetics in awake mouse ACx and mPFC; Pi 2013 Nature",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}