Details
- scope
- awake mouse ACx + mPFC; Vip-Cre + ChR2 + extracellular recording
- section_id
- section_05
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- effect_size
- 9/10 VIP neurons reward-responsive; punishment-driven response abrupt; ~20% of cortical neurons modulated by VIP optostimulation
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- source_span
- Water reward tended to generate somewhat weaker and more sustained firing rate increases (9/10 VIP neurons, half maximum duration 1.2s).
- study_system
- awake mouse ACx + mPFC; Vip-Cre + ChR2 + extracellular recording
- section_title
- Intrinsic Electrophysiology
- evidence_summary
- in vivo single-unit + optogenetics in awake mouse ACx and mPFC; Pi 2013 Nature
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
VIP interneurons in awake auditory cortex and mPFC receive strong, brief excitatory drive from reinforcement signals — both punishment (air-puff) and reward — eliciting abrupt firing-rate increases that occur after punishment delivery, with reward producing slower more sustained responses; this temporal pattern is consistent with VIP+ cells acting as a behavioral-event gate for cortical disinhibition.
- raw_fields
{ "n": null, "doi": "10.1038/nature12676", "claim": "VIP interneurons in awake auditory cortex and mPFC receive strong, brief excitatory drive from reinforcement signals — both punishment (air-puff) and reward — eliciting abrupt firing-rate increases that occur after punishment delivery, with reward producing slower more sustained responses; this temporal pattern is consistent with VIP+ cells acting as a behavioral-event gate for cortical disinhibition.", "title": null, "cite_key": "Pi2013", "evidence": "in vivo single-unit + optogenetics in awake mouse ACx and mPFC; Pi 2013 Nature", "effect_size": "9/10 VIP neurons reward-responsive; punishment-driven response abrupt; ~20% of cortical neurons modulated by VIP optostimulation", "text_access": "fulltext", "study_system": "awake mouse ACx + mPFC; Vip-Cre + ChR2 + extracellular recording", "_source_cluster": "cluster_04_intrinsic_electrophysiology", "replication_status": "replicated", "_source_cluster_index": 68, "claim_source_sentence": "Water reward tended to generate somewhat weaker and more sustained firing rate increases (9/10 VIP neurons, half maximum duration 1.2s).", "replication_evidence_dois": [ "10.1038/nn.4002" ], "effect_size_source_sentence": "Brief light stimulation of this sparse population of VIP-expressing interneurons (1–2% of cortical neurons) resulted in a disproportionately broad effect, generating significant firing rate changes in ~20% of cortical cells (ACx: 130/495, mPFC: 26/155)." }- source_refs
[ "paper:paper-065a0eae69a5" ]
- evidence_refs
[ { "ref": "paper:paper-065a0eae69a5" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }