Version history

{
  "scope": "Mouse OFC and DS networks; activity-dependent rabies tracing",
  "claim_text": "Anterograde monosynaptic-rabies-virus retrograde transfection enables ensemble-specific input mapping that revealed selectively strengthened orbitofrontal-cortex-to-dorsal-striatum cortico-cortical (across cortex-striatum) projections among co-activated neurons after cocaine, with >100,000 input neurons quantified.",
  "raw_fields": {
    "n": 100000,
    "doi": "10.1016/j.neuron.2019.10.032",
    "claim": "Anterograde monosynaptic-rabies-virus retrograde transfection enables ensemble-specific input mapping that revealed selectively strengthened orbitofrontal-cortex-to-dorsal-striatum cortico-cortical (across cortex-striatum) projections among co-activated neurons after cocaine, with >100,000 input neurons quantified.",
    "cite_key": "Wall2019",
    "evidence": "Activity-dependent complementary rabies-virus tracing of inputs to activated vs non-activated populations in mouse; optogenetic synaptic recording from cortical and DS neurons.",
    "effect_size": ">100,000 input neurons quantified across networks; potentiation specifically between coactive OFC and DS neurons (qualitative).",
    "text_access": "abstract_only",
    "study_system": "Mouse OFC and DS networks; activity-dependent rabies tracing",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "Analysis of over 100,000 synaptic input neurons demonstrated that cocaine-activated neurons comprise selectively connected but broadly distributed corticostriatal networks.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Electrophysiological assays using optogenetics to stimulate activated versus nonactivated inputs revealed stronger synapses between coactivated cortical pyramidal neurons and neurons in the dorsal striatum (DS)."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": ">100,000 input neurons quantified across networks; potentiation specifically between coactive OFC and DS neurons (qualitative).",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-6cf0e4fed5d6"
  ],
  "source_span": "Analysis of over 100,000 synaptic input neurons demonstrated that cocaine-activated neurons comprise selectively connected but broadly distributed corticostriatal networks.",
  "study_system": "Mouse OFC and DS networks; activity-dependent rabies tracing",
  "evidence_refs": [
    {
      "ref": "paper:paper-6cf0e4fed5d6"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Activity-dependent complementary rabies-virus tracing of inputs to activated vs non-activated populations in mouse; optogenetic synaptic recording from cortical and DS neurons.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}