Anterograde monosynaptic-rabies-virus retrograde transfection enables ensemble-…

Anterograde monosynaptic-rabies-virus retrograde transfection enables ensemble-specific input mapping that revealed selectively strengthened orbitofrontal-cortex-to-dorsal-striatum cortico-cortical (across cortex-striatum) projections among co-activated neurons after cocaine, with >100,000 input neurons quantified.

{
  "n": 100000,
  "doi": "10.1016/j.neuron.2019.10.032",
  "claim": "Anterograde monosynaptic-rabies-virus retrograde transfection enables ensemble-specific input mapping that revealed selectively strengthened orbitofrontal-cortex-to-dorsal-striatum cortico-cortical (across cortex-striatum) projections among co-activated neurons after cocaine, with >100,000 input neurons quantified.",
  "cite_key": "Wall2019",
  "evidence": "Activity-dependent complementary rabies-virus tracing of inputs to activated vs non-activated populations in mouse; optogenetic synaptic recording from cortical and DS neurons.",
  "effect_size": ">100,000 input neurons quantified across networks; potentiation specifically between coactive OFC and DS neurons (qualitative).",
  "text_access": "abstract_only",
  "study_system": "Mouse OFC and DS networks; activity-dependent rabies tracing",
  "argument_role": "supporting",
  "replication_status": "single-study",
  "claim_source_sentence": "Analysis of over 100,000 synaptic input neurons demonstrated that cocaine-activated neurons comprise selectively connected but broadly distributed corticostriatal networks.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Electrophysiological assays using optogenetics to stimulate activated versus nonactivated inputs revealed stronger synapses between coactivated cortical pyramidal neurons and neurons in the dorsal striatum (DS)."
}

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]

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