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- Live5/17/2026, 4:35:28 PM
86f08834d3e0Content snapshot
{ "scope": "mouse cortex (review/synthesis of multiple studies)", "claim_text": "Within the cortical VIP+ interneuron population, a major non-calretinin-coexpressing subtype is the rapid-adapting / fast-adapting / IS2 cell, which targets other interneurons (interneuron-selective IS2 functional class) and is electrophysiologically distinct from the VIP+/CR+ bipolar IS3-type population.", "raw_fields": { "n": null, "doi": "10.1002/dneu.20853", "claim": "Within the cortical VIP+ interneuron population, a major non-calretinin-coexpressing subtype is the rapid-adapting / fast-adapting / IS2 cell, which targets other interneurons (interneuron-selective IS2 functional class) and is electrophysiologically distinct from the VIP+/CR+ bipolar IS3-type population.", "title": null, "cite_key": "Rudy2011", "evidence": "Cross-referenced electrophysiological characterization studies (Butt 2005; Lee 2010; Miyoshi 2010; Porter 1998) plus VIP/CR co-expression analysis.", "effect_size": "VIP IS2 / rapid-adapting subtype is the major VIP+/CR- type", "figure_data": [], "text_access": "fulltext", "study_system": "mouse cortex (review/synthesis of multiple studies)", "_source_cluster": "cluster_02_development_lineage", "replication_status": "review", "_source_cluster_index": 112, "claim_source_sentence": "These cells have been named rapid-adapting ( Butt et al., 2005 ), fast-adapting ( Lee et al., 2010 ; Miyoshi et al., 2010 ), and IS2 ( Porter et al., 1998 ) and seem to be the major VIP subtype that does not coexpress CR.", "replication_evidence_dois": [ "10.1016/j.neuron.2005.09.034", "10.1523/jneurosci.1869-10.2010" ], "effect_size_source_sentence": "These cells have been named rapid-adapting ( Butt et al., 2005 ), fast-adapting ( Lee et al., 2010 ; Miyoshi et al., 2010 ), and IS2 ( Porter et al., 1998 ) and seem to be the major VIP subtype that does not coexpress CR." }, "section_id": "section_03", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json", "effect_size": "VIP IS2 / rapid-adapting subtype is the major VIP+/CR- type", "review_repo": "ComputationalReviewVIP", "section_ref": "wiki_page:computationalreviewvip-03-development", "source_kind": "review_finding", "source_path": "evidence/section_03_evidence_package.json", "source_refs": [ "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9" ], "source_span": "These cells have been named rapid-adapting ( Butt et al., 2005 ), fast-adapting ( Lee et al., 2010 ; Miyoshi et al., 2010 ), and IS2 ( Porter et al., 1998 ) and seem to be the major VIP subtype that does not coexpress CR.", "study_system": "mouse cortex (review/synthesis of multiple studies)", "evidence_refs": [ { "ref": "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9" } ], "section_title": "Developmental Origins and Postnatal Maturation", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }, "evidence_summary": "Cross-referenced electrophysiological characterization studies (Butt 2005; Lee 2010; Miyoshi 2010; Porter 1998) plus VIP/CR co-expression analysis.", "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827", "replication_status": "review", "review_package_ref": "analysis_bundle:ab-2ce40c33e827", "source_artifact_ref": "wiki_page:computationalreviewvip-03-development", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json", "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }