Version history

{
  "scope": "hAPP-transgenic mouse model of AD",
  "claim_text": "Nav1.1-overexpressing interneuron transplants enhance gamma oscillations and improve cognition in AD model mice, while Nav1.1-deficient transplants cause behavioral abnormalities in wild-type mice.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2018.02.029",
    "claim": "Nav1.1-overexpressing interneuron transplants enhance gamma oscillations and improve cognition in AD model mice, while Nav1.1-deficient transplants cause behavioral abnormalities in wild-type mice.",
    "evidence": "",
    "effect_size": "enhanced gamma oscillatory activity; improved cognitive functions",
    "text_access": "abstract_only",
    "study_system": "hAPP-transgenic mouse model of AD",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Nav1.1-overexpressing, but not wild-type, interneuron transplants derived from the embryonic medial ganglionic eminence enhance behavior-dependent gamma oscillatory activity, reduce network hypersynchrony, and improve cognitive functions in hAPP-transgenic mice.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Nav1.1-overexpressing, but not wild-type, interneuron transplants derived from the embryonic medial ganglionic eminence enhance behavior-dependent gamma oscillatory activity, reduce network hypersynchrony, and improve cognitive functions in hAPP-transgenic mice"
  },
  "section_id": "section_02_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json",
  "effect_size": "enhanced gamma oscillatory activity; improved cognitive functions",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-02",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-97c54b332720"
  ],
  "source_span": "Nav1.1-overexpressing, but not wild-type, interneuron transplants derived from the embryonic medial ganglionic eminence enhance behavior-dependent gamma oscillatory activity, reduce network hypersynchrony, and improve cognitive functions in hAPP-transgenic mice.",
  "study_system": "hAPP-transgenic mouse model of AD",
  "evidence_refs": [
    {
      "ref": "paper:paper-97c54b332720"
    }
  ],
  "section_title": "Molecular Identity and Transcriptomic Taxonomy",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-02",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}