Version history

{
  "scope": "mouse (fate-mapping + ex vivo and in vivo recording)",
  "claim_text": "GPe neurons of distinct developmental origins (Lhx6+ vs Nkx2.1+) produce specialized adult subpopulations: prototypic Lhx6/PV neurons project to STN, while arkypallidal Foxp2 neurons project back to striatum and encode movement differently.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2015.03.007",
    "claim": "GPe neurons of distinct developmental origins (Lhx6+ vs Nkx2.1+) produce specialized adult subpopulations: prototypic Lhx6/PV neurons project to STN, while arkypallidal Foxp2 neurons project back to striatum and encode movement differently.",
    "cite_key": "Dodson2015",
    "evidence": "Genetic fate mapping, electrophysiology, and tracing of GPe subpopulations in mouse.",
    "effect_size": "see source sentence",
    "text_access": "fulltext",
    "study_system": "mouse (fate-mapping + ex vivo and in vivo recording)",
    "source_cluster_id": "cluster_02",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Our data demonstrate that arkypallidal and prototypic neurons are defined by their mutually exclusive expression of FoxP2 and Nkx2-1, respectively (thus outlining a transcriptional “blueprint” for these cell types), establish that arkypallidal neurons constitute one-fifth of all mouse GPe neurons, and show that this functional dichotomy exists in the dopamine-intact brain and extends to other species.",
    "replication_evidence_dois": [
      "10.1016/j.isci.2025.113002"
    ],
    "effect_size_source_sentence": "Using unbiased, stereological cell counting in adult wild-type mice (see Figure S1 ), we determined that PPE-expressing (PPE+) GPe neurons also expressed the transcription factor forkhead box protein P2 (FoxP2), and vice versa, and that PPE+/FoxP2+ arkypallidal neurons constitute 20% of all GPe neurons ( Figures 1 A–1C)."
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_02_evidence_package.json",
  "effect_size": "see source sentence",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-02",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-4c9b05cf8ee7"
  ],
  "source_span": "Our data demonstrate that arkypallidal and prototypic neurons are defined by their mutually exclusive expression of FoxP2 and Nkx2-1, respectively (thus outlining a transcriptional “blueprint” for these cell types), establish that arkypallidal neurons constitute one-fifth of all mouse GPe neurons, and show that this functional dichotomy exists in the dopamine-intact brain and extends to other species.",
  "study_system": "mouse (fate-mapping + ex vivo and in vivo recording)",
  "evidence_refs": [
    {
      "ref": "paper:paper-4c9b05cf8ee7"
    }
  ],
  "section_title": "Classical Anatomy of the Triple Descending Projection",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Genetic fate mapping, electrophysiology, and tracing of GPe subpopulations in mouse.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-02",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_02_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}