Details
- scope
- mouse (fate-mapping + ex vivo and in vivo recording)
- claim_text
- GPe neurons of distinct developmental origins (Lhx6+ vs Nkx2.1+) produce specialized adult subpopulations: prototypic Lhx6/PV neurons project to STN, while arkypallidal Foxp2 neurons project back to striatum and encode movement differently.
- section_id
- section_02
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_02_evidence_package.json
- effect_size
- see source sentence
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-02
- source_kind
- review_finding
- source_path
- evidence/section_02_evidence_package.json
- study_system
- mouse (fate-mapping + ex vivo and in vivo recording)
- section_title
- Classical Anatomy of the Triple Descending Projection
- evidence_summary
- Genetic fate mapping, electrophysiology, and tracing of GPe subpopulations in mouse.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-02
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_02_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
- raw_fields
{ "n": null, "doi": "10.1016/j.neuron.2015.03.007", "claim": "GPe neurons of distinct developmental origins (Lhx6+ vs Nkx2.1+) produce specialized adult subpopulations: prototypic Lhx6/PV neurons project to STN, while arkypallidal Foxp2 neurons project back to striatum and encode movement differently.", "cite_key": "Dodson2015", "evidence": "Genetic fate mapping, electrophysiology, and tracing of GPe subpopulations in mouse.", "effect_size": "see source sentence", "text_access": "fulltext", "study_system": "mouse (fate-mapping + ex vivo and in vivo recording)", "source_cluster_id": "cluster_02", "replication_status": "independently_replicated", "claim_source_sentence": "Our data demonstrate that arkypallidal and prototypic neurons are defined by their mutually exclusive expression of FoxP2 and Nkx2-1, respectively (thus outlining a transcriptional “blueprint” for these cell types), establish that arkypallidal neurons constitute one-fifth of all mouse GPe neurons, and show that this functional dichotomy exists in the dopamine-intact brain and extends to other species.", "replication_evidence_dois": [ "10.1016/j.isci.2025.113002" ], "effect_size_source_sentence": "Using unbiased, stereological cell counting in adult wild-type mice (see Figure S1 ), we determined that PPE-expressing (PPE+) GPe neurons also expressed the transcription factor forkhead box protein P2 (FoxP2), and vice versa, and that PPE+/FoxP2+ arkypallidal neurons constitute 20% of all GPe neurons ( Figures 1 A–1C)." }- source_refs
[ "paper:paper-4c9b05cf8ee7" ]
- source_span
Our data demonstrate that arkypallidal and prototypic neurons are defined by their mutually exclusive expression of FoxP2 and Nkx2-1, respectively (thus outlining a transcriptional “blueprint” for these cell types), establish that arkypallidal neurons constitute one-fifth of all mouse GPe neurons, and show that this functional dichotomy exists in the dopamine-intact brain and extends to other species.
- evidence_refs
[ { "ref": "paper:paper-4c9b05cf8ee7" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }