Parkinson's disease tremor, freezing, and action sequencing impairments may be…

Parkinson's disease tremor, freezing, and action sequencing impairments may be explained by partially overlapping circuits including basal ganglia, cortex, and cerebellum, with cerebellum exerting strong disynaptic projection to striatum via thalamus.

{
  "n": 0,
  "doi": "10.1038/npjparkd.2016.25",
  "claim": "Parkinson's disease tremor, freezing, and action sequencing impairments may be explained by partially overlapping circuits including basal ganglia, cortex, and cerebellum, with cerebellum exerting strong disynaptic projection to striatum via thalamus.",
  "cite_key": "Caligiore2016b",
  "evidence": "Theoretical framework proposes that PD arises from dysfunction of the entire basal ganglia-cortex-cerebellum system, drawing on rodent and primate evidence for direct cerebellum-to-striatum disynaptic input.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "human and animal Parkinson's disease theoretical synthesis",
  "source_cluster_id": "cluster_06",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "In this respect, studies on rats 11 and monkeys 12 have demonstrated that Cer has a strong disynaptic projection to Str via the thalamus (Thal).",
  "replication_evidence_dois": [
    "10.3389/fnana.2016.00029",
    "10.1093/brain/aws360"
  ],
  "effect_size_source_sentence": null
}

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