Version history

{
  "scope": "human and animal Parkinson's disease theoretical synthesis",
  "claim_text": "Parkinson's disease tremor, freezing, and action sequencing impairments may be explained by partially overlapping circuits including basal ganglia, cortex, and cerebellum, with cerebellum exerting strong disynaptic projection to striatum via thalamus.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/npjparkd.2016.25",
    "claim": "Parkinson's disease tremor, freezing, and action sequencing impairments may be explained by partially overlapping circuits including basal ganglia, cortex, and cerebellum, with cerebellum exerting strong disynaptic projection to striatum via thalamus.",
    "cite_key": "Caligiore2016b",
    "evidence": "Theoretical framework proposes that PD arises from dysfunction of the entire basal ganglia-cortex-cerebellum system, drawing on rodent and primate evidence for direct cerebellum-to-striatum disynaptic input.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "human and animal Parkinson's disease theoretical synthesis",
    "source_cluster_id": "cluster_06",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "In this respect, studies on rats 11 and monkeys 12 have demonstrated that Cer has a strong disynaptic projection to Str via the thalamus (Thal).",
    "replication_evidence_dois": [
      "10.3389/fnana.2016.00029",
      "10.1093/brain/aws360"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-7bbe34025cb9"
  ],
  "source_span": "In this respect, studies on rats 11 and monkeys 12 have demonstrated that Cer has a strong disynaptic projection to Str via the thalamus (Thal).",
  "study_system": "human and animal Parkinson's disease theoretical synthesis",
  "evidence_refs": [
    {
      "ref": "paper:paper-7bbe34025cb9"
    }
  ],
  "section_title": "Parallel Loop Channels: Motor, Limbic, Associative, and Beyond the Classic Three",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Theoretical framework proposes that PD arises from dysfunction of the entire basal ganglia-cortex-cerebellum system, drawing on rodent and primate evidence for direct cerebellum-to-striatum disynaptic input.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}