An unsupervised classification approach applied to brain-wide single-neuron axo…

An unsupervised classification approach applied to brain-wide single-neuron axonal reconstructions from mouse primary motor cortex layer 6 recovers two distinct projection-neuron classes consistent with previously described cortico-thalamic and intra-telencephalic neuron classes, validating brain-wide axonal-projection clustering as a route to projection-class taxonomy.

{
  "n": null,
  "doi": "10.21203/rs.3.rs-3044664/v1",
  "claim": "An unsupervised classification approach applied to brain-wide single-neuron axonal reconstructions from mouse primary motor cortex layer 6 recovers two distinct projection-neuron classes consistent with previously described cortico-thalamic and intra-telencephalic neuron classes, validating brain-wide axonal-projection clustering as a route to projection-class taxonomy.",
  "cite_key": "Wheeler2023",
  "evidence": "Unsupervised statistical classification of brain-wide axonal-target patterns of single neurons reconstructed from mouse M1 layer 6 (validation) and mouse presubiculum.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse M1 layer 6 (cortico-thalamic vs intra-telencephalic projection classes)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "We first validate the proposed technique with well-characterized data from layer 6 of the mouse primary motor cortex. The results yield two clusters, consistent with previously discovered cortico-thalamic and intra-telencephalic neuron classes.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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We first validate the proposed technique with well-characterized data from layer 6 of the mouse primary motor cortex. The results yield two clusters, consistent with previously discovered cortico-thalamic and intra-telencephalic neuron classes.

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