Version history

{
  "scope": "whole-brain corticothalamic neural-mass model (matrix vs targeted thalamus)",
  "claim_text": "A whole-brain corticothalamic neural-mass model with empirically defined matrix and targeted thalamocortical projections recapitulates anesthetic suppression of integration/coherence; selective stimulation of the matrix thalamus restores wake-like cortical processing.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.celrep.2023.112844",
    "claim": "A whole-brain corticothalamic neural-mass model with empirically defined matrix and targeted thalamocortical projections recapitulates anesthetic suppression of integration/coherence; selective stimulation of the matrix thalamus restores wake-like cortical processing.",
    "cite_key": "Muller2023",
    "evidence": "Whole-brain corticothalamic neural-mass model parameterized with matrix vs targeted thalamocortical projections, validated against propofol/anesthesia signatures and macaque stimulation results.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "whole-brain corticothalamic neural-mass model (matrix vs targeted thalamus)",
    "source_cluster_id": "cluster_05",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We recover these signatures of conscious arousal by selectively stimulating the matrix thalamus, recapitulating empirical results in macaque, as well as wake-like information processing states that reflect the thalamic modulation of large-scale cortical attractor dynamics.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2024.04.019",
      "10.1016/s0166-2236(00)01922-6"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-06",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-d36d5d66b6f1"
  ],
  "source_span": "We recover these signatures of conscious arousal by selectively stimulating the matrix thalamus, recapitulating empirical results in macaque, as well as wake-like information processing states that reflect the thalamic modulation of large-scale cortical attractor dynamics.",
  "study_system": "whole-brain corticothalamic neural-mass model (matrix vs targeted thalamus)",
  "evidence_refs": [
    {
      "ref": "paper:paper-d36d5d66b6f1"
    }
  ],
  "section_title": "Thalamic Feedback: Closing the Loop",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Whole-brain corticothalamic neural-mass model parameterized with matrix vs targeted thalamocortical projections, validated against propofol/anesthesia signatures and macaque stimulation results.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-06",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}