A whole-brain corticothalamic neural-mass model with empirically defined matrix…

A whole-brain corticothalamic neural-mass model with empirically defined matrix and targeted thalamocortical projections recapitulates anesthetic suppression of integration/coherence; selective stimulation of the matrix thalamus restores wake-like cortical processing.

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  "n": 0,
  "doi": "10.1016/j.celrep.2023.112844",
  "claim": "A whole-brain corticothalamic neural-mass model with empirically defined matrix and targeted thalamocortical projections recapitulates anesthetic suppression of integration/coherence; selective stimulation of the matrix thalamus restores wake-like cortical processing.",
  "cite_key": "Muller2023",
  "evidence": "Whole-brain corticothalamic neural-mass model parameterized with matrix vs targeted thalamocortical projections, validated against propofol/anesthesia signatures and macaque stimulation results.",
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  "study_system": "whole-brain corticothalamic neural-mass model (matrix vs targeted thalamus)",
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  "replication_status": "independently_replicated",
  "claim_source_sentence": "We recover these signatures of conscious arousal by selectively stimulating the matrix thalamus, recapitulating empirical results in macaque, as well as wake-like information processing states that reflect the thalamic modulation of large-scale cortical attractor dynamics.",
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    "10.1016/j.neuron.2024.04.019",
    "10.1016/s0166-2236(00)01922-6"
  ],
  "effect_size_source_sentence": null
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We recover these signatures of conscious arousal by selectively stimulating the matrix thalamus, recapitulating empirical results in macaque, as well as wake-like information processing states that reflect the thalamic modulation of large-scale cortical attractor dynamics.

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