Version history

{
  "scope": "Mouse V1; optogenetic activation of A1→V1 axons + cell-type-specific recordings.",
  "claim_text": "In mouse V1, optogenetic activation of A1→V1 projections sharpens orientation selectivity of layer-2/3 (but not layer-4) excitatory neurons through layer-1-mediated inhibition–disinhibition, demonstrating that direct cortico-cortical inputs from primary auditory cortex modulate V1 sensory tuning via specific laminar circuits.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2016.01.027",
    "claim": "In mouse V1, optogenetic activation of A1→V1 projections sharpens orientation selectivity of layer-2/3 (but not layer-4) excitatory neurons through layer-1-mediated inhibition–disinhibition, demonstrating that direct cortico-cortical inputs from primary auditory cortex modulate V1 sensory tuning via specific laminar circuits.",
    "cite_key": "Ibrahim2016",
    "evidence": "Optogenetic activation of A1→V1 axons + whole-cell and population imaging in mouse V1; L1 manipulation to test mediation.",
    "effect_size": "L2/3 (not L4) excitatory neurons: decreased average response but increased preferred-orientation response; effect abolished by suppressing L1.",
    "text_access": "abstract_only",
    "study_system": "Mouse V1; optogenetic activation of A1→V1 axons + cell-type-specific recordings.",
    "argument_role": "supporting",
    "replication_status": "not_yet",
    "claim_source_sentence": "In mouse primary visual cortex (V1), we discovered that orientation selectivity of layer (L)2/3, but not L4, excitatory neurons was sharpened in the presence of sound or optogenetic activation of projections from primary auditory cortex (A1) to V1.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "It was more pronounced at lower visual contrast and was diminished by suppressing L1 activity."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "L2/3 (not L4) excitatory neurons: decreased average response but increased preferred-orientation response; effect abolished by suppressing L1.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-1a4df0a84e5a"
  ],
  "source_span": "In mouse primary visual cortex (V1), we discovered that orientation selectivity of layer (L)2/3, but not L4, excitatory neurons was sharpened in the presence of sound or optogenetic activation of projections from primary auditory cortex (A1) to V1.",
  "study_system": "Mouse V1; optogenetic activation of A1→V1 axons + cell-type-specific recordings.",
  "evidence_refs": [
    {
      "ref": "paper:paper-1a4df0a84e5a"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Optogenetic activation of A1→V1 axons + whole-cell and population imaging in mouse V1; L1 manipulation to test mediation.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "not_yet",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}