In mouse V1, optogenetic activation of A1→V1 projections sharpens orientation s…

In mouse V1, optogenetic activation of A1→V1 projections sharpens orientation selectivity of layer-2/3 (but not layer-4) excitatory neurons through layer-1-mediated inhibition–disinhibition, demonstrating that direct cortico-cortical inputs from primary auditory cortex modulate V1 sensory tuning via specific laminar circuits.

{
  "n": null,
  "doi": "10.1016/j.neuron.2016.01.027",
  "claim": "In mouse V1, optogenetic activation of A1→V1 projections sharpens orientation selectivity of layer-2/3 (but not layer-4) excitatory neurons through layer-1-mediated inhibition–disinhibition, demonstrating that direct cortico-cortical inputs from primary auditory cortex modulate V1 sensory tuning via specific laminar circuits.",
  "cite_key": "Ibrahim2016",
  "evidence": "Optogenetic activation of A1→V1 axons + whole-cell and population imaging in mouse V1; L1 manipulation to test mediation.",
  "effect_size": "L2/3 (not L4) excitatory neurons: decreased average response but increased preferred-orientation response; effect abolished by suppressing L1.",
  "text_access": "abstract_only",
  "study_system": "Mouse V1; optogenetic activation of A1→V1 axons + cell-type-specific recordings.",
  "argument_role": "supporting",
  "replication_status": "not_yet",
  "claim_source_sentence": "In mouse primary visual cortex (V1), we discovered that orientation selectivity of layer (L)2/3, but not L4, excitatory neurons was sharpened in the presence of sound or optogenetic activation of projections from primary auditory cortex (A1) to V1.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "It was more pronounced at lower visual contrast and was diminished by suppressing L1 activity."
}

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In mouse primary visual cortex (V1), we discovered that orientation selectivity of layer (L)2/3, but not L4, excitatory neurons was sharpened in the presence of sound or optogenetic activation of projections from primary auditory cortex (A1) to V1.

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